血管周围脂肪组织炎症反应参与主动脉夹层发生发展的研究进展  

Research progress of perivascular adipose tissue inflammation involved in the occurrence and development of aortic dissection

作　　者：王傲 邹明锐 韩曰信 王玉玖[1] Wang Ao;Zou Mingrui;Han Yuexin;Wang Yujiu(Department of Cardiovascular Surgery,Binzhou Medical University Hospital,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院心脏大血管外科,滨州256603

出　　处：《国际医药卫生导报》2024年第10期1590-1593,共4页International Medicine and Health Guidance News

基　　金：山东省自然科学基金(ZR2023MH067)。

摘　　要：主动脉夹层(AD)又称主动脉夹层动脉瘤,其起病凶险、病死率高。近年来,对其疾病进程中炎症指标变化的研究提示炎症与疾病临床转归的关系密切,且炎症反应最早出现在主动脉外膜及周围脂肪组织中。血管周围脂肪组织(PVAT)通过促炎机制介导动脉管壁炎症,与多种心血管疾病的发生发展密切相关。因此,针对PVAT炎症的检测及干预对研究AD早期病理生理变化以及AD高危人群早期预防具有重要意义。Aortic dissection(AD),also referred to as aortic dissection aneurysm,is a perilous condition associated with high mortality rate.Recent studies investigating the alterations in inflammatory markers during the disease progression suggest that inflammation plays a crucial role in determining the clinical outcomes of AD.The initial manifestation of inflammatory response occurs within the aortic adventitia and surrounding adipose tissue.Perivascular adipose tissue(PVAT)orchestrates arterial wall inflammation through proinflammatory mechanisms,which are closely linked to the occurrence and progression of various cardiovascular diseases.Consequently,detecting and intervening in PVAT inflammation holds immense significance for comprehending early pathophysiological changes in AD and implementing timely preventive measures among individuals at high risk.

关 键 词：主动脉夹层 血管周围脂肪组织 炎症 综述 

分 类 号：R543.1[医药卫生—心血管疾病]