基于静息态功能磁共振成像的紧张性头痛度中心度研究  

A study on the degree centrality of patients of tension-type headache based on resting state functional magnetic resonance imaging

作　　者：张淑娴[1] 巩平[1] 徐芹艳[1] 王吉丽 王锡臻[1] 王超[3] 孙西河[1] ZHANG Shuxian;GONG Ping;XU Qinyan;WANG Jili;WANG Xizhen;WANG Chao;SUN Xihe(Medical Imaging Center,Affiliated Hospital of Weifang Medical University,Weifang 261031,China;Department of Medical Imaging,Shouguang City People's Hospital,Weifang 262700,China;Department of Basic Support,Affiliated Hospital of Weifang Medical University,Weifang 261031,China)

机构地区：[1]潍坊医学院附属医院影像中心,潍坊261031 [2]寿光市人民医院影像科,潍坊262700 [3]潍坊医学院附属医院基础保障部,潍坊261031

出　　处：《磁共振成像》2024年第5期19-23,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：山东省自然科学基金项目(编号:ZR2017MH110);潍坊市卫健委项目(编号:WFWSJK-2023-349)。

摘　　要：目的采用静息态功能MRI(resting state functional MRI,rs-fMRI)度中心度(degree centrality,DC)探讨紧张性头痛(tension-type headache,TTH)患者在slow-4(0.027~0.073 Hz)和slow-5(0.010~0.027 Hz)频段的全脑网络节点中心性的改变及其与临床特征的相关性。材料与方法纳入自2018年5月~2019年7月到潍坊医学院附属医院神经内科就诊的TTH患者33例及与之匹配的健康对照38例,进行rs-fMRI扫描,利用DC的方法分析TTH组及健康对照组在slow-4(0.027~0.073 Hz)和slow-5(0.010~0.027 Hz)频段的DC值的差异,分析DC值的改变与疼痛程度、病程、疼痛发作频率的相关性。结果与健康对照组相比,在slow-5(0.010~0.027 Hz)频段,TTH组右侧额中回、右侧背外侧额上回的DC值显著增高;在slow-4(0.027~0.073 Hz)频段,TTH组与健康对照组的DC值差异无统计学意义[基于高斯随机场(Gaussian random field,GRF)校正,体素水平P<0.001,簇水平P<0.05]。另外,相关性分析的结果显示DC异常脑区与TTH患者的视觉模拟评分法(Visual Analog Scale,VAS)得分、病程、疼痛发作频率之间无显著相关性。结论额中回和额上回参与TTH疼痛信号的整合与处理,可能是TTH的关键中枢;slow-5(0.010~0.027 Hz)频段较slow-4(0.027~0.073 Hz)频段在探测TTH患者DC方面更敏感。Objective:To investigate the alterations in the centrality of whole brain network nodes of tension-type headache(TTH)patients in the slow-4(0.027-0.073 Hz)band and slow-5(0.010-0.027 Hz)band and the correlation with clinical features using resting state functional magnetic resonance imaging(rs-fMRI)with degree centrality(DC).Materials and Methods:Thirty-three patients with TTH who went to the Department of Neurology of Affiliated Hospital of Weifang Medical University from May 2018 to July 2019 and 38 matched healthy controls were collected for resting state functional magnetic resonance scanning.The method of degree centrality was used to analyze the difference of DC values in different frequency bands between TTH group and healthy control group.The correlation between the abnormal DC value and Visual Analog Scale(VAS)score,disease duration and headache attack frequency of TTH patients was analyzed.Results:Compared with the healthy control group,in the slow-5(0.010-0.027 Hz)frequency band,the DC values of the right middle frontal gyrus and the right dorsolateral superior frontal gyrus of TTH patients were significantly increased;however,in the slow 4(0.027-0.073 Hz)frequency band,there was no significant difference in DC value between TTH group and healthy control group(GRF correction,voxel level P<0.001,cluster level P<0.05).In addition,the results of correlation analysis showed that there was no significant correlation between abnormal DC brain regions and VAS scores,disease duration and headache attack frequency.Conclusions:The middle frontal gyrus and superior frontal gyrus were involved in the integration and processing of pain signals,so they might be the key hub of TTH;the slow-5 frequency band was more sensitive in detecting the DC value of TTH than the slow-4 frequency band.

关 键 词：紧张性头痛 度中心度 静息态功能磁共振成像 磁共振成像 频段特异性 

分 类 号：R445.2[医药卫生—影像医学与核医学] R747.2[医药卫生—诊断学]