孕中晚期胎儿海马折叠角变化的产前MRI研究  

Prenatal MRI of fetal hippocampal infolding angle change in middle and third trimester

作　　者：孙悦 曹一民 伊泽茜 孟卫新 周立霞[1] SUN Yue;CAO Yimin;YI Zexi;MENG Weixin;ZHOU Lixia(Department of Imaging,The Second Hospital of Hebei Medical University,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学第二医院影像科,石家庄050051

出　　处：《磁共振成像》2024年第5期24-27,101,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：北京康盟慈善基金会医学科研发展基金伦琴影像科研专项(编号:HB-201906-003)。

摘　　要：目的应用产前MRI研究孕中晚期胎儿海马折叠角(hippocampal infolding angle,HIA)的变化规律。材料与方法回顾性分析在河北医科大学第二医院2018年1月至2021年12月行产前MRI检查的孕中晚期正常胎儿影像学资料。于胎儿颅脑MRI的稳态采集快速成像(fast imaging employing steady state acquisition,FIESTA)序列冠状切面测量HIA,统计分析中晚孕期胎儿HIA的正常值范围,探讨其与孕龄变化的相关性以及临床应用价值。结果共有139例孕中晚期胎儿纳入研究,孕周20~38(29.17±3.90)周,男胎∶女胎=105∶34。按孕龄分为6组,分析得到胎儿海马折叠角的置信区间。随着孕龄增加,左右两侧HIA均呈线性增大(R^(2)=0.803、0.836,P均<0.001),且右侧HIA大于左侧,但未发现左右两侧存在性别间差异(P=0.898)。结论产前MRI发现孕中晚期胎儿HIA的变化具有一定的规律,可为宫内或生后与海马结构异常相关的疾病提供影像学诊断依据。Objective:Prenatal MRI was used to study the changes of the hippocampal infolding angle(HIA)of fetuses in the second and third trimester of pregnancy.Materials and Methods:The imaging data of normal fetuses in the second and third trimester of pregnancy undergoing prenatal MRI in the Second Hospital of Hebei Medical University from January 2018 to December 2021 were collected and were retrospectively analyzed.HIA in the coronal section of fetal brain MRI using the fast imaging employing steady state acquisition(FIESTA)sequence was measured,the normal range of HIA in fetuses in the second and third trimester of pregnancy was analyzed,to explore its correlation with gestational age changes and clinical application value.Results:A total of 139 cases of fetuses in the second and third trimester of pregnancy were included in the study,with a gestational age ranging from 20 to 38 weeks(mean 29.17±3.90 weeks),and a male-to-female ratio of 105∶34.The data was divided into 6 groups based on gestational age,and the confidence interval of fetal HIA was analyzed.With increasing gestational age,the HIA on both sides increased linearly(R^(2)=0.803,0.836,both P<0.001),and the HIA on the right side was greater than that on the left side.However,no gender differences were found in the left and right sides(P=0.898).Conclusions:Prenatal MRI revealed that the changes of the HIA in fetuses in the second and third trimester of pregnancy follows a certain pattern,which can provide imaging diagnostic evidence for diseases related to hippocampal structural abnormalities either in utero or after birth.

关 键 词：胎儿 海马折叠角 磁共振成像 发育 海马结构 

分 类 号：R445.2[医药卫生—影像医学与核医学] R714.5[医药卫生—诊断学]