磁共振3D-T1WI及扩散成像在阿尔茨海默病中的研究进展  

Research progress of magnetic resonance 3D-TIWI and diffusion imaging in Alzheimer's disease

作　　者：李琳钦 段欢芹 邱丽华 LI Linqin;DUAN Huanqin;QIU Lihua(School of Medical and Life Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Medical Imaging Center,Second People's Hospital of Yibin,Yibin 644000,China;Department of Radiology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;Clinical Medical Research and Transformation Center,the Second People's Hospital of Yibin City-West China Yibin Hospital,Sichuan Univerity,Neuroimaging Big Data Research Center,Yibin 644000,China)

机构地区：[1]成都中医药大学医学与生命科学学院,成都611137 [2]宜宾市第二人民医院医学影像中心,宜宾644000 [3]川北医学院附属医院放射科,南充637000 [4]宜宾市第二人民医院·四川大学华西医院宜宾医院临床医学研究与转化中心,神经影像大数据研究中心,宜宾644000

出　　处：《磁共振成像》2024年第5期181-186,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家重点研发计划项目(编号:2022YFC2009901,2022YFC2009900);四川省卫健委科技项目(编号:23LCYJ021)。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是最常见的神经退行性疾病,主要症状为进行性记忆下降和认知功能障碍,发病率呈上升趋势,目前缺乏有效的治疗手段,因此,早期诊断、预防及延缓AD的进展至关重要。近年来,MRI已广泛应用于AD及其他认知障碍领域的研究,三维T1加权成像(three-dimensional T1 weighted imaging,3D-T1WI)、扩散MRI可以客观、间接地反映异常的大脑结构变化,为解释其机制提供影像学依据。本文从3D-T1WI、扩散MRI在AD中的应用展开综述,从多个角度探索AD患者脑结构变化及病理生理机制,为AD的早期诊断提供帮助。Alzheimer's disease(AD)is the most common neurodegenerative disease.The main symptoms are progressive memory decline and cognitive dysfunction.The incidence rate is on the rise,and there is a lack of effective treatment.Therefore,early diagnosis,prevention and delay of AD are essential.In recent years,MRI has been widely used in the study of AD and other cognitive impairment fields.Three-dimensional T1 weighted imaging(3D-T1WI),diffusion MRI can objectively and indirectly reflect abnormal brain structural changes,providing imaging evidence for explaining their mechanisms.This article provides a review of the application of 3D-T1WI,diffusion MRI in AD,exploring the changes in brain structure and pathophysiological mechanisms of AD patient from multiple perspectives,and providing assistance for the early diagnosis of AD.

关 键 词：阿尔茨海默病 磁共振成像 三维T1加权成像 扩散张量成像 扩散峰度成像 神经突方向离散度和密度成像 脑结构 病理生理机制 早期诊断 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.16[医药卫生—诊断学]