定量磁化率成像在阿尔茨海默病诊断及病程进展跟踪中的应用研究  

Study on the application of quantitative susceptibility mapping in the diagnosis and progression tracking of Alzheimer's disease

作　　者：王瑞奇 詹逸珺 裴建[1] WANG Ruiqi;ZHAN Yijun;PEI Jian(Department of Acupuncture and Moxibustion,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院针灸科,上海200032

出　　处：《磁共振成像》2024年第5期187-191,197,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：上海市科委重点科研项目(编号:22Y11922900,18401970500);上海市卫健委海派中医流派传承研究项目[编号:ZY(2021-2023)-0209-10,ZY(2018-2020)-CCCX-1006];上海申康重大临床研究项目(编号:SHDC2020CR3091B)。

摘　　要：阿尔茨海默病(Aizheimer’s disease,AD)是一种中枢神经系统的退行性疾病,脑内铁稳态失调被认为是AD重要的病理学特征之一。定量磁化率成像(quantitative susceptibility mapping,QSM)作为一种无创MRI技术,对铁的存在非常敏感,能够以高空间分辨率来量化局部组织磁化率。近年来,QSM技术已经对不同脑区的磁化率以及与其他病理生物标志物之间的关系进行了研究,本文旨在分析铁稳态失调对AD病理的影响以及QSM技术在AD早期诊断及病程跟踪方面的潜在应用价值,为AD的早期诊断及治疗提供客观的神经影像学依据。Alzheimer's disease(AD)is a degenerative disease of the central nervous system,and dysregulation of iron homeostasis in the brain is one of the important pathological features of AD.Quantitative susceptibility mapping(QSM),a noninvasive magnetic resonance technique,is sensitive to the presence of iron and can quantify local tissue magnetization with high spatial resolution.In recent years,the QSM technique has been investigated on the magnetization rate of different brain regions and the relationship with other pathological biomarkers.The aim of this paper is to analyze the effect of iron homeostasis dysregulation on the pathology of AD as well as the potential value of the QSM technique in the early diagnosis of AD and tracking of the disease course,to provide objective neuroimaging basis for the early diagnosis and treatment of AD.

关 键 词：阿尔茨海默病 定量磁化率成像 磁共振成像 铁稳态失调 脑铁沉积 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.16[医药卫生—诊断学]