肾上腺皮质球状带细胞的电兴奋性与醛固酮分泌:离子通道的作用  

Electrical excitability and aldosterone secretion in the zona glomerulosa cells:the role of ion channels

作　　者：张雪峰 胡长龙[1] ZHANG Xuefeng;HU Changlong(School of Life Sciences,Fudan University,Shanghai 200434,China)

机构地区：[1]复旦大学生命科学学院,上海200434

出　　处：《基础医学与临床》2024年第6期753-757,共5页Basic and Clinical Medicine

基　　金：上海市自然科学基金(23ZR1425900)。

摘　　要：醛固酮是肾上腺皮质球状带(ZG)细胞产生的类固醇类激素,对体液电解质平衡和血压稳定起着关键调控作用。醛固酮生成是一个钙离子依赖性的过程,离子通道在这一过程中扮演着关键角色。临床上发现的原发性醛固酮增多症大多与离子通道的突变有关。最近ZG细胞独特的rosette结构与其电兴奋性的关系引起了更多研究兴趣。阐明rosette与ZG细胞电兴奋性以及醛固酮分泌之间的关系,有助于更深入地了解调节醛固酮分泌的机制,为原发性醛固酮增多症的发病机制提供新见解。Aldosterone is a kind of steroid hormone produced by the zona glomerulosa(ZG)cells of the adrenal cortex which plays a crucial regulatory role in fluid-electrolyte balance and blood pressure stability.Aldosterone biosynthesis is a calcium-dependent process,and ion channels play a key role in this process.Primary aldosteronism is closely related to mutations in ion channels.Recent studies have highlighted an intriguing relationship between the unique rosette structure of ZG cells and their electrical excitability.Elucidating the connection between rosettes and ZG cell electrical excitability as well as aldosterone secretion leads to a deeper understanding of the mechanisms regulating aldosterone secretion and may provide new insights into the pathogenesis of primary aldosteronism.

关 键 词：肾上腺皮质球状带细胞 电兴奋性 醛固酮 离子通道 rosette结构 

分 类 号：Q454[生物学—生理学]