Acute suppurative terminal cholangitis:Clinical characteristics of a new subtype of acute cholangitis  

作　　者：Rong-Tao Zhu Ye Li Chi-Xian Zhang Wei-Jie Wang Ruo-Peng Liang Jian Li Kai Bai Yu-Ling Sun 

机构地区：[1]Department of Hepatobiliary and Pancreatic Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China [2]Zhengzhou Key Laboratory of Hepatobiliary and Pancreatic Diseases,Zhengzhou 450052,China [3]Institute of Hepatobiliary and Pancreatic Diseases,Zhengzhou University,Zhengzhou 450052,China [4]Department of Pathology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China

出　　处：《Hepatobiliary & Pancreatic Diseases International》2024年第3期293-299,共7页国际肝胆胰疾病杂志（英文版）

基　　金：This study was supported by a grant from the National Natural Science Foundation of China(81870457).

摘　　要：Background:Acute suppurative terminal cholangitis(ASTC)is rarer than acute obstructive cholangitis and is not well studied.To explore this subtype of acute cholangitis,we described our clinical experience with ASTC.Methods:We performed a retrospective review of patients with ASTC admitted to our center from September 2014 to August 2020.We analyzed their clinical characteristics,including etiology,clinical manifestations,imaging features,treatment and prognosis.Results:A total of 32 ASTC patients were included in the analysis.The majority of the patients had a history of biliary operations,and clinical manifestations were occult and atypical.The positive rate of bacterial culture was 46.9%.All the patients had typical imaging features on computed tomography and magnetic resonance imaging.Treatment with effective antibiotics was provided as soon as diagnosis was established.After treatment,most patients had a good outcome.Elevated levels of total bilirubin,aspartate aminotransferase,procalcitonin and gamma-glutamyltransferase were the characteristics of critically ill patients and were associated with relatively poor prognosis.Conclusions:Our results demonstrated that ASTC should be recognized as a new subtype of acute cholangitis,and that earlier diagnosis and more personalized treatments are needed.

关 键 词：Acute suppurative terminal cholangitis Acute cholangitis Gram-negative bacterial infections DIAGNOSIS Treatment 

分 类 号：R657.45[医药卫生—外科学]