半乳糖凝集素3及血小板与淋巴细胞比值与75岁以上急性心肌梗死患者术后心室重构的关系  

Relationship of galectin-3and PLR with postoperative ventricular remodeling in patients over 75years old with AMI

作　　者：张新贵[1] 王长虹 王进[1] Zhang Xingui;Wang Changhong;Wang Jin(Department of General Medicine,Nanyang First People's Hospital,Nanyang473000,Henan Province,China)

机构地区：[1]南阳市第一人民医院全科医学科,473000

出　　处：《中华老年心脑血管病杂志》2024年第5期504-507,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨外周血半乳糖凝集素3(Gal-3)、血小板与淋巴细胞比值(PLR)水平变化及其与75岁以上急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后发生心室重构的关系。方法选择2021年3月至2023年9月在南阳市第一人民医院择期行PCI术的75岁以上老年AMI患者86例,根据PCI术后是否发生心室重构将患者分为心室重构组39例和非心室重构组47例。于PCI术前、术后3d、术后5d检测Gal-3、PLR水平,比较2组外周血Gal-3、PLR水平,用多因素logistic回归分析外周血Gal-3、PLR水平与老年AMI患者PCI术后发生心室重构的关系,用ROC曲线分析外周血Gal-3、PLR水平对老年AMI患者PCI术后发生心室重构的预测价值。结果2组患者术后3d、术后5d外周血Gal-3、PLR水平均较术前降低,且术后5d外周血Gal-3、PLR水平低于术后3d(P<0.05);心室重构组术前、术后3d、术后5d的外周血Gal-3、PLR水平均高于非心室重构组(P<0.05,P<0.01)。多因素logistic回归分析显示,术前Gal-3(OR=1.986,95%CI:1.017~2.875,P=0.007)、术前PLR(OR=1.774,95%CI:1.132~2.428,P=0.014)均是AMI患者PCI术后发生心室重构的危险因素。ROC曲线显示,术前外周血Gal-3和PLR联合预测AMI患者PCI术后发生心室重构的曲线下面积为0.882(95%CI:0.824~0.941),优于二者单独检测(P<0.05)。结论AMI患者PCI术后外周血Gal-3、PLR水平较术前降低,术前外周血Gal-3、PLR均是PCI术后发生心室重构的危险因素,联合检测对AMI患者PCI术后发生心室重构有较高预测价值。Objective To investigate the changes in peripheral blood galectin-3(Gal-3)and platelet to lymphocyte ratio(PLR)and their relationship with ventricular remodeling in elderly patients over 75years old with acute myocardial infarction(AMI)after PCI.Methods A total of 86AMI patients(aged≥75years)undergoing elective PCI in our hospital from March 2021to September 2023were recruited in this study.According to ventricular remodeling occurred or not after PCI,they were divided into ventricular remodeling group(39cases)and non-ventricular remodeling group(47cases).Gal-3level and PLR were detected and calculated before and in 3and 5dafter PCI,and the results were compared between the two groups.Multivariate logistic regression analysis was used to analyze the relationship of Gal-3and PLR with ventricular remodeling in elderly AMI patients after PCI,and ROC curve was plotted to study the predictive value of the two indicators for ventricular remodeling.Results In the elderly AMI patients,the levels of Gal-3and PLR were decreased in 3and 5dafter PCI than before operation,and the levels at 5dwere lower than those of 3dafter operation(P<0.05).The ventricular remodeling group had obviously higher levels of Gal-3and PLR in peripheral blood than the non-ventricular remodeling group before and in 3and 5dafter PCI(P<0.05,P<0.01).Multivariate logistic regression analysis showed that Gal-3(OR=1.986,95%CI:1.017-2.875,P=0.007)and PLR(OR=1.774,95%CI:1.132-2.428,P=0.014)were risk factors for ventricular remodeling in AMI patients after PCI.ROC curve indicated that the AUC value of combined Gal-3and PLR before PCI in predicting ventricular remodeling in the AMI patients after PCI was 0.882(95%CI:0.824-0.941),which was superior to the value of the two indicator alone(P<0.05).Conclusion The levels of Gal-3and PLR in peripheral blood are lower in the elderly AMI patients after PCI than before PCI,and the two indicators are risk factors for ventricular remodeling in these patients after PCI.Combined detection of them has high predictive val

关 键 词：心肌梗死 心室重构 半乳糖凝集素3 血小板与淋巴细胞比值 

分 类 号：R542.22[医药卫生—心血管疾病]