二仙汤合桂枝茯苓丸加减治疗PCOS对患者代谢紊乱及卵巢血流动力学的改善作用  

Improvement effect of the metabolic disorders and the ovarian hemodynamics of patients with polycystic ovary syndrome treated by Erxian decoction combined with Guizhi fuling pills modifications

作　　者：金萍萍 李伟莉 王培培 JIN Pingping;LI WeiLi;WANG Peipei(Anhui University of Traditional Chinese Medicine,Hefei,Anhui Province,230000;Tongcheng Traditional Chinese Medicine Hospital,Tongcheng,Anhui Province;The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei;Lu'an Traditional Chinese Medicine Hospital,Anhui Province)

机构地区：[1]安徽中医药大学,合肥230000 [2]安徽省桐城市中医医院 [3]安徽中医药大学第一附属医院 [4]安徽省六安市中医院

出　　处：《中国计划生育学杂志》2024年第5期1037-1042,共6页Chinese Journal of Family Planning

摘　　要：目的:观察二仙汤合桂枝茯苓丸加减治疗多囊卵巢综合征(PCOS)疗效及对患者代谢紊乱、卵巢血流动力学的影响。方法:将2021年3月-2023年3月本院就诊的PCOS患者104例分为两组,对照组(n=52)给予炔雌醇环丙孕酮片治疗,观察组(n=52)给予炔雌醇环丙孕酮片联合二仙汤合桂枝茯苓丸加减治疗,治疗3个月经周期后评估疗效。检测血清性激素及代谢指标,超声测量卵巢间质动脉收缩期峰值血流速度(PSV)、阻力指数(RI)和舒张末期血流速度(EDV)。结果:治疗后观察组中医证候积分(5.58±1.89分)、血清睾酮(2.01±0.33nmol/L)、空腹血糖(4.65±0.37mmol/L)、黄体生成素(7.12±0.64U/L)、总胆固醇(4.11±0.32mmol/L)、黄体生成素/卵泡刺激素(1.31±0.12)、低密度脂蛋白胆固醇(2.46±0.31mmol/L)、空腹胰岛素(11.07±2.65)、三酰甘油(1.09±0.19mmol/L)均低于对照组(7.96±2.03分、2.74±0.42nmol/L、5.22±0.51mmol/L、9.34±0.85U/L、4.52±0.36mmol/L、1.72±0.21、2.67±0.43mmol/L、12.89±2.97、1.23±0.21mmol/L),雌二醇(68.85±5.96ng/L)水平高于对照组(62.48±5.17ng/L)(均P<0.05),但两组卵泡刺激素和高密度脂蛋白胆固醇水平无差异(P>0.05),卵巢PSV(12.21±1.98cm/s)、EDV(10.02±2.17cm/s)均低于对照组(15.88±2.01cm/s、11.53±2.25cm/s),RI(0.82±0.21)和治疗总有效率(98.1%)均高于对照组(0.62±0.13、84.6%)(均P<0.05)。结论:二仙汤合桂枝茯苓丸加减治疗PCOS能够改善患者临床症状,纠正内分泌及糖脂代谢紊乱,改善卵巢血流动力学,提高临床疗效。Objective:To observe the effect of Erxian decoction combined with Guizhi fuling pills modifications for treating patients with polycystic ovary syndrome(PCOS),and to study its influence on the metabolic disorders and the ovarian hemodynamics of the patients.Methods:104patients with PCOS who visited the hospital and had been treated with Ethinylestradiol cyproterone acetate tablets were randomly divided into two groups(52cases in each group)from March 2021to March 2023.The patients in the observation group were treated with Erxian decoction combined with Guizhi fuling pills modifications additionally.The therapeutic effect of the patients in the two groups after three menstrual cycles of treatment was evaluated.The serum sex hormones and the metabolic indicators of the patients in the two groups were detected.The values of peak systolic blood flow velocity(PSV),resistance index(RI)and end diastolic blood flow velocity(EDV)of ovarian interstitial artery of the patients in the two groups were measured by ultrasound.Results:After treatment,the TCM syndrome score(5.58±1.89points),the serum testosterone level(2.01±0.33nmol/L),the fasting blood glucose level(4.65±0.37mmol/L),the luteinizing hormone level(7.12±0.64U/L),the total cholesterol level(4.11±0.32)mmol/L,the ratio of luteinizing hormone/follicle stimulating hormone(1.31±0.12),the low density lipoprotein cholesterol level(2.46±0.31mmol/L),the fasting insulin(11.07±2.65)and the triglyceride level(1.09±0.19mmol/L)of the patients in the observation group were significantly lower than those(7.96±2.03points,2.74±0.42nmol/L,5.22±0.51mmol/L,9.34±0.85U/L,4.52±0.36mmol/L,1.72±0.21,2.67±0.43mmol/L,12.89±2.97and 1.23±0.21mmol/L)of the patients in the control group,and the level of estradiol(68.85±5.96ng/L)of the patients in the observation group was significantly higher than that(62.48±5.17ng/L)of the patients in the control group(all P<0.05).There was no significant difference in the levels of follicle stimulating hormone and high-density lipoprotein ch

关 键 词：多囊卵巢综合征 二仙汤 桂枝茯苓丸 炔雌醇环丙孕酮片 血糖血脂 性激素 卵巢血流动力学 中医症候 

分 类 号：R271.9[医药卫生—中西医结合]