妊娠期尖锐湿疣患者外周血IL-17、NF-κB水平及与妊娠结局的相关性  

Correlation between the levels of interleukin-17 and nuclear transcription factor-κin peripheral blood of pregnant women with gestational condyloma acuminatum during pregnancy and their pregnancy outcomes

作　　者：刘瑞 王亚玲 赵小娟 赵红 LIU Rui;WANG Yaling;ZHAO Xiaojuan;ZHAO Hong(Northwest Women and Children Hospital,Xi'an,Shaanxi Province,710061)

机构地区：[1]西北妇女儿童医院,西安710061

出　　处：《中国计划生育学杂志》2024年第5期1180-1184,1189,共6页Chinese Journal of Family Planning

摘　　要：目的:分析妊娠期尖锐湿疣患者外周血白介素-17(IL-17)、核转录因子-κB(NF-κB)水平及与妊娠结局关系。方法:回顾性收集本院2014年9月-2023年9月收治的137例妊娠期尖锐湿疣患者纳入观察组,按性别、年龄匹配原则,以1:1比例选取同期本院产前检查健康孕产妇137例作为对照组;统计两组妊娠结局及外周血白细胞介素-17(IL-17)、核转录因子-κB(NF-κB)水平,按妊娠结局将观察组分为良好组与不良组,比较两组临床资料及外周血IL-17、NF-κB水平,logistic回归分析外周血IL-17、NF-κB水平与妊娠期尖锐湿疣患者妊娠结局关系;采用受试者工作特征(ROC)曲线分析妊娠尖锐湿疣患者外周血IL-17、NF-κB水平对妊娠结局的评估价值。结果:两组均未见产后出血发生,观察组剖宫产率(37.2%)高于对照组(1.5%),不良妊娠结局总发生率(13.9%)高于对照组(0),外周血IL-17(91.27±28.33pg/ml)、NF-κB(8.66±4.05ng/ml)水平均高于对照组(15.31±4.04pg/ml、4.22±1.63ng/ml);观察组137例中19例妊娠结局不良,余118例良好,两组年龄、孕周、既往孕产史、疣体数目、疣体面积及HPV分型无差异(P>0.05),结局不良组外周血IL-17(121.20±16.90pg/ml)、NF-κB(14.87±4.60ng/ml)水平高于结局良好组(86.45±30.17pg/ml、7.66±3.96ng/ml)(均P<0.05)。logistic回归分析显示,外周血IL-17、NF-κB水平是妊娠尖锐湿疣患者妊娠结局不良的危险因素(P<0.05);ROC曲线显示,妊娠尖锐湿疣患者外周血IL-17、NF-κB评估妊娠结局时以NF-κB的曲线下面积(0.949)高于IL-17(0.884),两项串联评估的特异度为97.5%。结论:妊娠期尖锐湿疣患者外周血IL-17、NF-κB异常升高,患者妊娠结局不良风险增加且血IL-17、NF-κB与妊娠结局有关,外周血NF-κB与IL-17联合检测评估妊娠期尖锐湿疣不良妊娠结局高特异度优势值得临床重视。Objective:To analyze the correlation between the levels of interleukin-17(IL-17)and nuclear transcription factor-κ(NF-κB)in peripheral blood of pregnant women with gestational condyloma acuminatum during pregnancy and their pregnancy outcomes.Methods:A total of 137patients with gestational condyloma acuminatum admitted to hospital from September 2014to September 2023were included in observation group retrospectively.According to the matching principle of gender and age by 1:1ratio,137healthy pregnant women who received routine pregnancy examination in the hospital during the same period were selected in control group.The pregnancy outcomes,and the IL-17and NF-κB levels in peripheral blood of the women in the two groups were counted.The women in the observation group were divided into group A(the women with normal pregnancy outcomes)and group B(the women with adverse pregnancy outcomes)according to the pregnancy outcomes of the women.The clinical data and the IL-17,NF-κB levels in peripheral blood of the women were compared between group A and group B.The correlation between the IL-17and NF-κB levels in peripheral blood of the women with gestational condyloma acuminatum and their pregnancy outcomes was analyzed by logistic regression.Receiver operating characteristic(ROC)curve was used to analyze the value of the IL-17and NF-κB levels in peripheral blood of the women with gestational condyloma acuminatum for evaluating their pregnancy outcomes.Results:There was no any woman with postpartum hemorrhage in these groups.The cesarean section rate(37.2%)and the total incidence of adverse pregnancy outcomes(13.9%)of the women in the observation group were significantly higher than those(1.5%and 0)of the women in the control group.The levels of IL-17(91.27±28.33pg/ml)and NF-κB(8.66±4.05ng/ml)in peripheral blood of the women in the observation group were significantly higher than those(15.31±4.04pg/ml and 4.22±1.63ng/ml)of the women in the control group.Among 137 women in the observation group,there were 19cases

关 键 词：妊娠期尖锐湿疣 白细胞介素-17 核转录因子?κB 妊娠结局 相关性 评估 

分 类 号：R714.2[医药卫生—妇产科学] R752.53[医药卫生—临床医学]