加味小半夏汤穴位贴敷联合二联止吐药对顺铂所致CINV的疗效观察  

Clinical observation of acupoint application of Jiawei Weixiaobanxia Tang combined with Two antiemetic drugs on CINV caused by cisplatin

作　　者：苏丹 郑圣齐[1] Su Dan;Zheng Shengqi(People's Liberation Army Navy Anqing Hospital,Anqing 246000,China)

机构地区：[1]中国人民解放军海军安庆医院中西医结合肿瘤科,安徽省安庆市246000

出　　处：《现代养生》2023年第1期36-39,共4页Health Protection and Promotion

摘　　要：目的 探讨加味小半夏汤穴位贴敷联合常规二联止吐方案(阿扎司琼+地塞米松)预防和减轻顺铂所致化疗相关性恶心呕吐(chemotherapy induced nausea and vomiting,CINV)的临床疗效。方法 将2020年1月-2022年1月在中国人民解放军海军安庆医院进行含顺铂双药方案化疗的60例非小细胞肺癌(NSCLC)患者,按照组间性别、年龄、BMI指数、肿瘤类型、KPS评分均衡可比的原则,采用随机数字表法分为观察组和对照组,每组30例。观察组给予加味小半夏汤穴位贴敷联合阿扎司琼+地塞米松静滴的二联止吐方案治疗,对照组仅给予阿扎司琼+地塞米松静滴二联止吐治疗。比较两组患者顺铂用药后第1、3、5天的呕吐程度、化疗致恶心呕吐及干呕评价量表(R-INVR)评分及临床疗效,并记录皮肤不良反应情况。结果 两组患者用药后呕吐均呈减轻趋势,用药第1天两组总有效率比较,差异无统计学意义(P>0.05);而第3、5天观察组总有效率均高于对照组,差异均有统计学意义(P<0.05)。观察组顺铂用药后第1、3、5天的R-INVR评分均低于对照组,且第3、5天组间比较,差异有统计学意义(P<0.05)。观察组皮肤不良反应轻微,未见严重过敏反应。结论 加味小半夏汤穴位贴敷联合二联止吐方案可有效减轻顺铂所致胃肠道反应,且皮肤毒性低。Objective To study the effect of Jiawei Xiaobanxia Tang acupoint application combined with conventional two combined antiemetic regimen(azasetron+dexamethasone) on preventing and reducing chemotherapy induced nausea and vomiting induced by cisplatin. Methods A total of 60 patients with non-small cell lung cancer(NSCLC)who received cisplatin-containing dual-drug chemotherapy in Anqing Hospital of PLA Navy from January 2020 to January 2022 were randomly divided into observation group and control group according to the principle of balanced and comparable gender, age, BMI index, tumor type, and KPS score between groups. Each group had 30 cases.The observation group was treated with Jiawei Xiaobanxia Tang acupoint application combined with azasetron and dexamethasone, while the control group was only treated with azasetron and dexamethasone. The degree of vomiting,R-INVR score and clinical efficacy were compared between the two groups on the 1st, 3rd and 5th day after cisplatin treatment, and the skin adverse reactions were recorded. Results Vomiting of patients in both groups showed a trend of reduction after medication. The total effective rate of the control group was lower than that of the observation group on the first day of medication, but the difference was not statistically significant(P>0.05);On the 3rd and 5th day, the total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). After cisplatin treatment, the R-INVR score of the observation group was lower than that of the control group on the 1st, 3rd and 5th day, and the difference was statistically significant between the groups on the 3rd and 5th day(P<0.05). In the observation group, skin adverse reactions were mild, and no severe allergic reactions were observed. Conclusion Jiawei Xiaobanxia Tang acupoint application combined with two combined antiemetic regimen can effectively reduce gastrointestinal reactions caused.

关 键 词：加味小半夏汤 穴位贴敷 化疗相关性恶心呕吐 化疗 肺癌 

分 类 号：R271.9[医药卫生—中西医结合]