健脾止动汤联合阿立哌唑改善小儿多发性抽动症患儿肌肉功能及行为异常的效果研究  

Effect of Jianpi Zhidong Decoction combined with aripiprazole in improving muscle function and behavioral abnormality in children with pediatric multiple tics

作　　者：王一君 WANG Yijun(Department of Child Care,the First People′s Hospital of Datong City in Shanxi Province,Datong,Shanxi,037000)

机构地区：[1]山西省大同市第一人民医院儿保科,山西大同037000

出　　处：《实用临床医药杂志》2024年第8期104-108,共5页Journal of Clinical Medicine in Practice

摘　　要：目的探讨健脾止动汤联合阿立哌唑对小儿多发性抽动症患儿肌肉功能及行为异常的效果。方法选取90例小儿多发性抽动症患儿为研究对象,随机分为阿立哌唑组和止动汤组,每组45例。比较2组疗效、肌肉功能评分、行为抽动评分、神经功能评分及不良反应发生情况。结果治疗后,止动汤组治疗总有效率为82.22%,高于阿立哌唑组的44.44%,差异有统计学意义(P<0.05)。治疗后,2组抽动强度评分、抽动次数评分及抽动频率评分均降低,且止动汤组上述评分低于阿立哌唑组,差异均有统计学意义(P<0.05)。治疗后,2组发声性抽动评分、运动性抽动评分均降低,且止动汤组上述评分低于阿立哌唑组,差异均有统计学意义(P<0.05)。治疗后,2组5-羟色胺(5-HT)、多巴胺(DA)水平降低,且止动汤组5-HT、DA水平低于阿立哌唑组,差异均有统计学意义(P<0.05);治疗后,2组甲肾上腺素(NE)、γ-氨基丁酸(GABA)水平升高,且止动汤组NE、GABA水平高于阿立哌唑组,差异均有统计学意义(P<0.05)。止动汤组不良反应发生率为6.67%,低于阿立哌唑组的26.67%,差异有统计学意义(P<0.05)。结论健脾止动汤联合阿立哌唑治疗小儿多发性抽动症疗效显著,可有效改善患儿肌肉功能、异常行为、神经功能,降低不良反应发生率,且安全性较好。Objective To investigate the effects of Jianpi Zhidong Decoction combined with aripiprazole on muscle function and behavioral abnormality in children with pediatric multiple tics.Methods A total of 90 children with pediatric multiple tics were selected as research objects,and they were randomly divided into aripiprazole group and Zhidong Decoction group,with 45 cases in each group.The efficacy,score of muscle function,score of behavioral tics,score of neurological function and incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate was 82.22%in the Zhidong Decoction group,which was significantly higher than 44.44%in the aripiprazole group(P<0.05).After treatment,the score of tics intensity,score of number of tics and score of tics frequency in both groups decreased significantly,and scores of these indexes in the Zhidong Decoction group were significantly lower than those in the aripiprazole group(P<0.05).After treatment,the score of vocal tic and score of motor tic in both groups decreased significantly,and the scores of these indexes in the Zhidong Decoction group were significantly lower than those in the aripiprazole group(P<0.05).After treatment,the levels of 5-hydroxytryptamine(5-HT)and dopamine(DA)in both groups decreased significantly,and the levels of 5-HT and DA in the Zhidong Decoction group were significantly lower than those in the aripiprazole group(P<0.05);after treatment,the levels of norepinephrine(NE)andγ-aminobutyric acid(GABA)in both groups increased significantly,and the levels of NE and GABA in the Zhidong Decoction group were significantly higher than those in the aripiprazole group(P<0.05).The incidence rate of adverse reactions was 6.67%in the Zhidong Decoction group,which was significantly lower than 26.67%in the aripiprazole group(P<0.05).Conclusion The combination of Jianpi Zhidong Decoction and aripiprazole has a significant therapeutic effect in treating children with pediatric multiple tics,which can effectively improve m

关 键 词：健脾止动汤 阿立哌唑 小儿多发性抽动症 肌肉功能 行为异常 

分 类 号：R729[医药卫生—儿科] R337[医药卫生—临床医学] R242