抗中性粒细胞胞浆抗体相关性血管炎研究进展  

Research progress of anti-neutrophil cytoplasmic antibody associated vasculitis

作　　者：李媛媛 郝健 LI Yuanyuan;HAO Jian(Inner Mongolia Medical University,Hohhot,Inner Mongolia,010050;Department of Nephrology,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia,010050)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院肾内科,内蒙古呼和浩特010050

出　　处：《实用临床医药杂志》2024年第7期143-148,共6页Journal of Clinical Medicine in Practice

基　　金：内蒙古自治区自然科学基金项目(2022MS08036)。

摘　　要：抗中性粒细胞胞浆抗体(ANCA)相关性血管炎(AAV)是一类以小血管壁炎症和纤维素样坏死为特征,累及全身多系统的自身免疫性疾病。亚洲地区AAV以显微镜下多血管炎(MPA)为主,最常累及肾和肺。近几年发现补体,例如C5a,通过替代途径在AAV的发病机制中发挥着重要作用,所以了解AAV补体与凝血过程之间的联系有利于从发病机制出发找到治疗疾病的靶点。本综述总结AAV发病机制中凝血及纤溶系统变化及与补体系统相互作用的研究进展。Anti-neutrophil cytoplasmic antibody(ANCA)associated vasculitis(AAV)is a class of autoimmune diseases characterized by inflammation of the small vessel wall and fibrinoid necrosis that can involve multiple systems throughout the body.AAV in the Asian region is mainly characterized by microscopic polyangitis(MPA),which most commonly affects the kidneys and lungs.In recent years,it has been discovered that complement such as C5a plays an important role in the pathogenesis of AAV through alternative pathways.Therefore,understanding the relationship between AAV complement and coagulation processes is beneficial for identifying therapeutic targets from the perspective of pathogenesis.This review summerized the research progress on the changes in coagulation and fibrinolysis systems and their interactions with the complement system in the pathogenesis of AAV.

关 键 词：抗中性粒细胞胞浆抗体 相关性血管炎 补体 凝血 纤溶系统 

分 类 号：R593.2[医药卫生—内科学] R456[医药卫生—临床医学] R392