信迪利单抗治疗肺腺癌后发生反向性扁平苔藓  

Reversed lichen planus during treatment with sintilimab for lung adenocarcinoma

作　　者：范文[1] 曹雪琛 雷娜 苏忠兰[1] 鲁严[1] FAN Wen;CAO Xuechen;LEI Na;SU Zhonglan;LU Yan(Department of Dermatology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院皮肤科,江苏南京210029

出　　处：《临床皮肤科杂志》2024年第5期284-286,共3页Journal of Clinical Dermatology

基　　金：南京医科大学科研基金(2023LX100)资助项目。

摘　　要：报告1例程序性死亡受体1(PD-1)抑制剂信迪利单抗治疗过程中出现的反向扁平苔藓。患者男,73岁,双侧腋下和腹股沟红褐色斑疹4个月。发疹前3个月因肺腺癌开始使用PD-1抑制剂信迪利单抗。皮肤科检查:双侧腋下和腹股沟可见沿皱褶方向对称分布的散在灰褐色斑片,Wickman征(+)。右腋下皮损组织病理检查:颗粒层部分楔形增厚,较广泛的基底膜液化变性,真皮浅层淋巴细胞带状浸润,可见较多嗜色素颗粒,并可见胶样小体。诊断为反向性扁平苔藓。A case of reversed lichen planus developing during treatment with sintilimab for lung adenocarcinoma is reported.A 73-year-old man iad erythema rash on bilateral armpits and groins for 4 months.He had used sintilimab 3 months before the onset of rash for lung adenocarcinoma.Physical examination revealed scattered flat gray-brown macules symmetrically distributed along the folds,with Wickman's sign(+).Histopathological examination showed partial wedge-shaped thickening of the granular layer,extensive liquefaction of the basement membrane.The superficial dermis was surrounded by band-like lymphocytes,chromophore granules.The patient was diagnosed as reverse lichen planus.

关 键 词：扁平苔藓 反向性 肺腺癌 程序性死亡受体1 

分 类 号：R758.65[医药卫生—皮肤病学与性病学]