真皮脂肪调控毛发生长的研究进展  

Research progress in regulation of hair growth by dermal adipose tissue

作　　者：张悦 汤炜[2] 田卫东[1,2] 于湄[1] ZHANG Yue;TANG Wei;TIAN Weidong;YU Mei(National Engineering Laboratory for Oral Regenerative Medicine,West China School of Stomatology,Sichuan University,Chengdu Sichuan,610041,P.R.China;Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu Sichuan,610041,P.R.China)

机构地区：[1]四川大学华西口腔医学院、口腔再生医学国家地方联合工程实验室,成都610041 [2]四川大学华西口腔医院口腔颌面创伤整形外科,成都610041

出　　处：《中国修复重建外科杂志》2024年第5期626-632,共7页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金区域创新发展联合基金(U21A20369);四川省科技计划重点研发项目(2019YFS0312);四川大学华西口腔医学院交叉学科创新项目(RD-03-202303)。

摘　　要：目的总结毛发周期和真皮脂肪之间的动态同步变化以及真皮脂肪对毛发生长的影响,为临床治疗脱发提供新的研究思路。方法广泛查阅国内外相关文献,分析和总结真皮脂肪前体细胞、真皮成熟脂肪细胞以及成脂分化过程对毛发周期转变的影响。结果真皮脂肪组织与毛囊解剖结构相邻,并且与毛发周期变化息息相关。真皮脂肪前体细胞的增殖分化促进毛发由静止期向生长期转变,但成熟脂肪细胞能够通过表达调节毛发周期的信号分子以加速毛发周期生长期-退行期转变。真皮脂肪的成脂分化与毛发周期转变共同受到多种信号通路的综合调节。结论真皮脂肪通过分泌多种信号分子来影响毛发周期转变以调节毛发生长,但目前研究结果尚不足以充分阐明真皮脂肪在调节毛发周期中的突出作用,具体调节机制有待进一步研究。Objective To summarize the dynamic and synchronized changes between the hair cycle and dermal adipose tissue as well as the impact of dermal adipose tissue on hair growth,and to provide a new research idea for the clinical treatment of hair loss.Methods An extensive review of relevant literature both domestic and international was conducted,analyzing and summarizing the impact of dermal adipose precursor cells,mature dermal adipocytes,and the processes of adipogenesis in dermal adipose tissue on the transition of hair cycle phases.Results Dermal adipose tissue is anatomically adjacent to hair follicles and closely related to the changes in the hair cycle.The proliferation and differentiation of dermal adipose precursor cells promote the transition of hair cycle from telogen to anagen,while mature adipocytes can accelerate the transition from anagen to catagen of the hair cycle by expressing signaling molecules,with adipogenesis in dermal adipose tissue and hair cycle transition signaling coexistence.Conclusion Dermal adipose tissue affects the transition of the hair cycle and regulates hair growth by secreting various signaling molecules.However,the quantity and depth of existing literature are far from sufficient to fully elucidate its prominent role in regulating the hair cycle,and the specific regulatory mechanisms needs to be further studied.

关 键 词：真皮脂肪前体细胞 真皮成熟脂肪细胞 毛发周期 信号分子 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]