从风论治小细胞肺癌  

Treatment of Small Cell Lung Cancer from the Perspective of Wind

作　　者：黄蓉 贾立群 王瑞韬 孙建荣 刘青[2] HUANG Rong;JIA Liqun;WANG Ruitao;SUN Jianrong;LIU Qing(School of Clinical Medicine,Beijing University of Chinese Medicine,Beijing,100029;China-Japan Friendship Hospital)

机构地区：[1]北京中医药大学临床医学院,北京市100029 [2]中日友好医院

出　　处：《中医杂志》2024年第9期949-953,共5页Journal of Traditional Chinese Medicine

基　　金：北京市重大疑难疾病中西医协同攻关对标项目(序号4小细胞肺癌);2021年岐黄学者支持项目(2021-QHXZ-02)。

摘　　要：认为风邪是小细胞肺癌的核心致病因素之一,风邪的性质及致病特点与小细胞肺癌的发生和转移密切相关。小细胞肺癌正虚以气阴两虚为主,易受外风侵袭,同时存在阴虚生风、血虚生风、痰瘀毒生风、肝阳化风等内风病机,内外风相合而致发病。提出从风论治小细胞肺癌的观点,即益气养阴以熄风,药用太子参、五味子等;化痰行瘀以祛风,药用僵蚕、木蝴蝶、防风、天麻、全蝎等祛风化痰,当归、川芎、丹参等活血祛风;攻毒散结以剔风,药用水蛭、地龙、蜂房、全蝎、白花蛇、九香虫等药性峻猛之剂;平肝熄风以预防小细胞肺癌脑转移,方用天麻钩藤饮加减。It is believed that wind pathogen is one of the core pathogenic factors of small cell lung cancer(SCLC).The nature and pathogenic characteristics of wind pathogen are closely related to the occurrence and metastasis of SCLC.Mainly manifested as deficiency of both qi and yin,healthy qi deficiency of SCLC makes it susceptible to invasion of external wind.Simultaneously,there are internal wind pathogenesis such as yin deficiency causing wind,blood deficiency causing wind,phlegm,stasis and toxin causing wind,liver yang transforming into wind.The internal and external winds together lead to the disease.Therefore,it is proposed to treat SCLC from wind theory,that is,boosting qi and nourishing yin to extinguish wind with taizishen(Radix Pseudostellariae),wuweizi(Fructus Schisandrae Chinensis)and others;resolving phlegm and moving stasis to dispel wind with wind-dispelling and phlegm-resolving medicinals such as jiangcan(Bombyx Batryticatus),muhudie(Semen Oroxyli),fangfeng(Radix Saposhnikoviae),tianma(Rhizoma Gastrodiae),quanxie(Scorpio)and blood-invigorating and wind-dispelling medi-cinals such as danggui(Radix Angelicae Sinensis),chuanxiong(Rhizoma Chuanxiong)and danshen(Radix et Rhizoma Salviae Miltiorrhizae);attacking toxin and dissipating masses to dispel wind with shuizhi(Hirudo),dilong(Pheretima),fengfang(Nidus Vespae),quanxie,baihuashe(Agkistrodon),jiuxiangchong(Aspongopus)and other drastic medicinals;calming liver and extinguishing wind to prevent brain metastasis of SCLC with Tianma Gouteng Beverage(天麻钩藤饮)modification.

关 键 词：小细胞肺癌 风邪 气阴两虚 

分 类 号：R273[医药卫生—中西医结合]