部分城市父母对儿童无细胞百白破、乙型肝炎、灭活脊髓灰质炎和b型流感嗜血杆菌成分疫苗接种方案偏好的离散选择实验  

Parental preferences for childhood vaccination regimens with diphtheria,tetanus,and acellular pertussis;hepatitis B;inactivated poliovirus;and Haemophilus influenzae type b containing vaccines:a discrete choice experiment in selected cities

作　　者：黄澳迪 许侠 唐林 黄丽芳[3] 张雪 周洋[4] 张倩[1,2] 周泽玫 王钰 王晓琪[1,2] 刘倩倩 刘斯宇 尹遵栋[1,2] 王富珍[1,2] Huang Aodi;Xu Xia;Tang Lin;Huang Lifang;Zhang Xue;Zhou Yang;Zhang Qian;Zhou Zemei;Wang Yu;Wang Xiaoqi;Liu Qianqian;Liu Siyu;Yin Zundong;Wang Fuzhen(National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Chinese Center for Disease Control and Prevention,Bejing 102206,China;National Immunization Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China;Fujian Provincial Center for Disease Control and Prevention,Fuzhou 350012,Fujian,China;Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,Zhejiang,China)

机构地区：[1]传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心,北京102206 [2]中国疾病预防控制中心免疫规划中心,北京100050 [3]福建省疾病预防控制中心,福建福州350012 [4]浙江省疾病预防控制中心,浙江杭州310051

出　　处：《中国疫苗和免疫》2024年第2期127-133,共7页Chinese Journal of Vaccines and Immunization

基　　金：中国CDC公共卫生应急反应机制的运行(131031001000150001)。

摘　　要：目的调查儿童父母对儿童无细胞百白破(DTaP)、乙型肝炎(HepB)、灭活脊髓灰质炎(IPV)和b型流感嗜血杆菌(Hib)成分疫苗接种方案的选择偏好。方法采用离散选择试验和便利抽样方法在中国3个城市地区6个预防接种门诊选择0-6岁儿童的父母开展问卷调查。使用混合Logit模型估计DTaP、HepB、IPV和Hib成分疫苗接种方案选择偏好的参数值和选择概率。结果共纳入220例研究对象。混合Logit模型回归分析显示,疫苗接种方案的接种剂次数最少(β=3.40,95%CI:3.03-3.77)和一般反应发生率最低(β=2.56,95%CI:2.18-2.94)是影响研究对象选择偏好最重要的属性;不同特征研究对象的选择偏好存在异质性。当疫苗接种方案为接种5剂次、一般反应发生率1/50、自付费用800元和进口疫苗时,研究对象的选择概率提高至99.83%。结论研究地区儿童父母对儿童疫苗接种方案的选择偏好主要受接种剂次数和疫苗安全性的影响;需开发和应用更多更安全的儿童联合疫苗。Objective To explore parental preferences for childhood vaccination regimens with diphtheria,tetanus,and acellular pertussis(DTaP);hepatitis B(HepB);inactivated poliovirus(IPV);and Haemophilus influenzae type b(Hib)containing vaccines.Methods We recruited a convenience sample of parents of 0-6-year-old children from 6 vaccination clinics in 3 cities of China and conducted a questionnaire-based discrete choice experiment.We used a mixed logit model to estimate parameter values of preferences for different vaccination regimens with DTaP,HepB,IPV,and/or Hib containing vaccines and probabilities of choices.Results A total of 220 subjects were recruited into the study.Mixed logit regression showed that fewest scheduled doses(β=3.40,95%CI:3.03-3.77)and lowest incidence of common vaccine reactions(β=2.56,95%CI:2.18-2.94)were the most important preferences.There was heterogeneity of preferences by characteristics of the subjects.A 5-dose schedule using imported vaccines with an incidence of common reaction of 1/50 costing parents 800 yuan had a probability of choice of 99.83%.Conclusions Parental preferences for combination childhood vaccine regimens were most influenced by the number of doses required and the safety of the vaccine.More safe combination vaccines should be developed and used for children.

关 键 词：疫苗接种 接种方案 偏好 离散选择实验 儿童父母 

分 类 号：R186[医药卫生—流行病学] R195[医药卫生—公共卫生与预防医学]