中国健康人群破伤风IgG抗体水平Meta分析  

A meta-analysis of tetanus antibody levels among healthy populations in China

作　　者：陈娅妮 胡莹雪 郑徽[1,2] 刘艳[3] 安志杰[1,2] Chen Yani;Hu Yingxue;Zheng Hui;Liu Yan;An Zhijie(National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease,Chinese Center for Disease Control and Prevention,Beijing 102206,China;National Immunization Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China;Hangzhou Center for Disease Control and Prevention,Hangzhou 310021,Zhejiang,China)

机构地区：[1]传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心,北京102206 [2]中国疾病预防控制中心免疫规划中心,北京100050 [3]杭州市疾病预防控制中心,浙江杭州310021

出　　处：《中国疫苗和免疫》2024年第2期231-236,共6页Chinese Journal of Vaccines and Immunization

摘　　要：目的分析中国健康人群破伤风抗体水平。方法通过中英文文献数据库检索2000-2023年发表的中国健康人群破伤风抗体水平相关研究文献,对纳入文献进行Meta分析,计算破伤风IgG抗体阳性(≥0.01IU/mL)率和保护(≥0.1IU/mL)率的合并效应值。结果共纳入34篇文献,覆盖中国15个省份,研究总样本量为30741例。Meta分析显示,全健康人群破伤风抗体阳性率、保护率的合并效应值分别为80.81%(95%CI:72.54%-87.90%)、55.15%(95%CI:44.32%-65.74%)。<1岁、1-2岁、3-4岁、5-6岁、7-14岁、15-19岁、20-39岁、≥40岁阳性率合并效应值分别为98.86%、98.67%、98.15%、95.86%、91.22%、86.08%、82.96%、48.73%(χ^(2)=38.64,P<0.001),保护率合并效应值分别为89.65%、92.60%、90.20%、87.58%、71.54%、43.18%、23.68%、12.56%(χ^(2)=259.03,P<0.001)。结论中国健康人群破伤风抗体水平总体较高且随年龄增长呈下降趋势;需完善人群破伤风免疫策略。Objective To analyze tetanus antibody levels in healthy populations in China.Methods We retrieved research studies on tetanus antibody levels in healthy Chinese populations published from 2000 to 2023 from Chinese and English language databases.We conducted meta-analyses of included studies to estimate pooled tetanus IgG antibody positive(≥0.01IU/mL)rates and protective(≥0.1IU/mL)rates.Results A total of 34 studies were included,involving 15 provinces of China,with a total sample size of 30741 subjects.Meta-analysis showed that pooled positivity and protection rates in healthy Chinese populations were 80.81%(95%CI:72.54%-87.90%)and 55.15%(95%CI:44.32%-65.74%),respectively.Pooled positivity rates for<1-,1-2-,3-4-,5-6-,7-14-,15-19-,20-39-,and≥40-year-olds were 98.86%,98.67%,98.15%,95.86%,91.22%,86.08%,82.96%,and 48.73%(χ^(2)=38.64,P<0.001),with pooled protection rates being 89.65%,92.60%,90.20%,87.58%,71.54%,43.18%,23.68%,and 12.56%(χ^(2)=259.03,P<0.001).Conclusions The tetanus antibody level was generally high in healthy populations in China and decreased with increasing age.We suggest improving tetanus immunization strategies for Chinese populations.

关 键 词：破伤风 IGG抗体 META分析 

分 类 号：R181.2[医药卫生—流行病学]