免疫球蛋白使用者疫苗接种研究和实践现状综述  

Research and immunization practices for patients receiving immunoglobulin preparations:a literature review

作　　者：程祖瑶 郭旭 宋渝丹[1,2] 王亚敏[1,2] 李军宏[1,2] 贾亚超 尹遵栋[1,2] 马超[1,2] Cheng Zuyao;Guo Xu;Song Yudan;Wang Yamin;Li Junhong;Jia Yachao;Yin Zundong;Ma Chao(National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Chinese Center for Disease Control and Prevention,Beijing 102206,China;National Immunization Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China)

机构地区：[1]传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心,北京102206 [2]中国疾病预防控制中心免疫规划中心,北京100050

出　　处：《中国疫苗和免疫》2024年第2期258-263,共6页Chinese Journal of Vaccines and Immunization

基　　金：中华预防医学会新冠疫情防控模型研究项目。

摘　　要：免疫球蛋白制剂通常用于被动免疫治疗,与疫苗的同时使用可能会影响疫苗的免疫应答,合理确定免疫球蛋白使用与疫苗接种之间的时间间隔是良好免疫实践的重要考虑。本文对有关免疫球蛋白影响疫苗免疫应答的文献、世界卫生组织和主要国家发布的相关指南、疫苗产品说明书等进行了综述,为完善中国疫苗免疫实践提供参考。Immunoglobulin preparations are commonly used for passive immune therapy.Simultaneous administration of immunoglobulins and vaccines may impact the immune response to vaccines.Therefore,a key for good immunization practices is to determine appropriate intervals between immunoglobulin administration and vaccination.In this article,we review scientific literatures about the impact of immunoglobulins on vaccine responses,relevant guidelines issued by the World Health Organization and several countries,and guidelines and prescribing information(package inserts)for vaccines used in China to provide reference for improving immunization practices in China.

关 键 词：免疫球蛋白 疫苗接种 时间间隔 

分 类 号：R186[医药卫生—流行病学]