间接队列设计在疫苗保护效果评价中的应用  

Use of an indirect cohort design for evaluation of vaccine effectiveness

作　　者：李玖洪 唐林 王富珍[1,2] 尹遵栋[1,2] Li Jiuhong;Tang Lin;Wang Fuzhen;Yin Zundong(National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Chinese Center for Disease Control and Prevention,Beijing 102206,China;National Immunization Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China)

机构地区：[1]传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心,北京102206 [2]中国疾病预防控制中心免疫规划中心,北京100050

出　　处：《中国疫苗和免疫》2024年第2期264-268,共5页Chinese Journal of Vaccines and Immunization

基　　金：中国CDC公共卫生应急反应机制的运行(102393220020010000017)。

摘　　要：疫苗上市后保护效果(Vaccine effectiveness,VE)评价是对疫苗在真实世界应用后预防控制疾病效果的流行病学评估。间接队列设计(Indirect cohort design,ICD)是一种利用疫苗针对疾病患者的疫苗接种史和感染病原体血清型的个体水平数据计算VE的方法,可以有效减少样本量、降低研究成本且具有较高可信度。本文对ICD的原理、在疫苗上市后VE评价中的应用、优势和局限性等方面进行了综述,旨在帮助研究人员更好地了解和合理运用ICD。Post-marketing vaccine effectiveness(VE)evaluation is an epidemiological assessment of vaccinations to prevent and control diseases in the real world.The indirect cohort design(ICD)is a study design that uses individual-level vaccination history data and infecting pathogen serotypes of patients with vaccine-targeted diseases to calculate VE.An ICD can effectively reduce sample size,lower study cost,and retain high credibility.In this article,we review principles,post-marketing VE evaluations,and advantages and limitations of ICD,aiming to help researchers better understand and conduct ICD VE evaluations.

关 键 词：间接队列设计 疫苗 保护效果 

分 类 号：R186[医药卫生—流行病学] R331[医药卫生—公共卫生与预防医学]