Emergence of SARS and COVID-19 and preparedness for the next emerging disease X  

作　　者：Ben Hu Hua Guo Haorui Si Zhengli Shi 

机构地区：[1]CAS Key Laboratory of Special Pathogens and Biosafety,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,430071,China [2]University of Chinese Academy of Sciences,Beijing,100049,China

出　　处：《Frontiers of Medicine》2024年第1期1-18,共18页医学前沿（英文版）

基　　金：supported by the National Key Research and Development Program of China(Nos.2022YFC2305101 and 2021YFC0863400);the Strategic Research and Consulting Program of Chinese Academy of Engineering(No.2022-JB-06-04).

摘　　要：Severe acute respiratory syndrome(SARS)and Coronavirus disease 2019(COVID-19)are two human Coronavirus diseases emerging in this century,posing tremendous threats to public health and causing great loss to lives and economy.In this review,we retrospect the studies tracing the molecular evolution of SARS-CoV,and we sort out current research findings about the potential ancestor of SARS-CoV-2.Updated knowledge about SARS-CoV-2-like viruses found in wildlife,the animal susceptibility to SARS-CoV-2,as well as the interspecies transmission risk of SARS-related coronaviruses(SARSr-CoVs)are gathered here.Finally,we discuss the strategies of how to be prepared against future outbreaks of emerging or re-emerging coronaviruses.

关 键 词：SARS COVID-19 CORONAVIRUS 

分 类 号：R373[医药卫生—病原生物学]