富血小板血浆在神经病理性疼痛中的作用机制研究进展  

Research Progress in Mechanism of Platelet-rich Plasma in Neuropathic Pain

作　　者：鞠衍馨 田德民[2] 原金凤 JU Yanxin;TIAN Demin;YUAN Jinfeng(Department of Anesthesiology,the 970th Hospital of Joint Support Force of Chinese PLA,Weihai 264200,China;Department of Painology,Weihai Municipal Hospital,Weihai 264200,China)

机构地区：[1]联勤保障部队第九七〇医院麻醉科,山东威海264200 [2]威海市立医院疼痛科,山东威海264200

出　　处：《医学综述》2024年第12期1420-1424,共5页Medical Recapitulate

摘　　要：神经系统的组织损伤、炎症、创伤及原发性病变等损害性因素可导致伤害性神经元过度兴奋而诱发异位电活动产生神经病理性疼痛(NP)。富血小板血浆(PRP)富含大量细胞因子及生长因子,可阻止促炎介质释放并促进抗炎介质释放,进而促进炎症消退,并促进受损神经轴突再生和局部神经再支配,加快感觉、运动神经传导速度的恢复,降低神经元的过度兴奋,改善和消除NP。PRP所释放的细胞因子的抗炎及镇痛作用可能会为NP的治疗提供一种新思路。Damage factors such as tissue injury,inflammation,trauma and primary lesions of the nervous system can lead to excessive excitation of noxious neurons and induce ectopic electrical activity to produce neuropathic pain(NP).Platelet-rich plasma(PRP)is rich in a large number of cytokines and growth factors,which can prevent the release of pro-inflammatory mediators and promote the release of anti-inflammatory mediators,thus promoting the regression of inflammation,promoting the regeneration of damaged nerve axons and local nerve reinnervation,accelerating the recovery of sensory and motor nerve conduction velocity,reducing the over excitation of neurons,and improving and eliminating NP.The anti-inflammatory and analgesic effects of cytokines released by PRP may provide a new idea for the treatment of NP.

关 键 词：神经病理性疼痛 富血小板血浆 炎症 细胞因子 神经修复 

分 类 号：R318[医药卫生—生物医学工程] R457[医药卫生—基础医学]