尼可刹米在无痛胃肠镜检查麻醉中的应用效果分析  

Application Effect Analysis of Nikethamide in Anesthesia of Painless Gastrointestinal Endoscopy

作　　者：李国福 张学伟 王玉娥 陈仁义 史斌 刘立赛 Li Guofu;Zhang Xuewei;Wang Yu'e;Chen Renyi;Shi Bin;Liu Lisai(Department of Anesthesiology,Linyi Cancer Hospital,Linyi 276000,Shandong Province,China;Department of Special Inspection,Linyi Cancer Hospital,Linyi 276000,Shandong Province,China;Department of Pathology,Linyi Cancer Hospital,Linyi 276000,Shandong Province,China)

机构地区：[1]临沂市肿瘤医院麻醉科,山东临沂276000 [2]临沂市肿瘤医院特检科,山东临沂276000 [3]临沂市肿瘤医院病理科,山东临沂276000

出　　处：《中国社区医师》2024年第10期50-52,共3页Chinese Community Doctors

基　　金：山东省医药卫生科技发展计划项目(编号:202103030190)。

摘　　要：目的:探讨尼可刹米在无痛胃肠镜检查麻醉中的应用效果。方法:选取2023年9—11月于临沂市肿瘤医院实施无痛胃肠镜检查的120例患者作为研究对象,根据随机数字表法分成两组,各60例。两组均采用丙泊酚复合舒芬太尼进行麻醉,试验组麻醉诱导前静脉注射尼可刹米,对照组麻醉诱导前静脉注射等体积生理盐水。比较两组生命体征、不良事件发生情况。结果:麻醉前(T_(0))、麻醉给药后10 min(T_(4))、麻醉给药后15 min(T_(5))时,两组血氧饱和度(SpO_(2))比较,差异无统计学意义(P>0.05);麻醉给药后1 min(T_(1))、麻醉给药后3 min(T_(2))、麻醉给药后5 min(T_(3))时,两组SpO_(2)均低于T_(0),但试验组高于对照组,差异有统计学意义(P<0.001)。T_(0)时,两组平均动脉压(MAP)比较,差异无统计学意义(P>0.05);T_(1)、T_(2)、T_(3)、T_(4)、T_(5)时,两组MAP均低于T_(0),但试验组高于对照组,差异有统计学意义(P<0.001)。T_(0)、T_(1)、T_(2)、T_(3)、T_(5)时,两组心率(HR)比较,差异无统计学意义(P>0.05);T_(4)时,两组HR均低于T_(0),但试验组高于对照组,差异有统计学意义(P=0.003)。试验组不良事件总发生率均低于对照组,差异有统计学意义(P<0.001)。结论:尼可刹米在无痛胃肠镜检查麻醉中的应用效果较好,能够稳定生命体征,减少不良事件。Objective:To explore the application effect of nikethamide in painless gastrointestinal endoscopy anesthesia.Methods:A total of 120 patients who underwent painless gastrointestinal endoscopy in Linyi Cancer Hospital from September 2023 to No-vember 2023 were selected as the study subjects.They were divided into two groups with 60 cases in each group according to the random number table method.Both groups were anesthetized with propofol combined with sufentanil,the experimental group was intravenously injected with nikethamide before anesthesia induction,and the control group was intravenously injected with equal volume of normal saline before anesthesia induction.The vital signs and occurrence of adverse events between the two groups was compared.Results:There was no significant difference in blood oxygen saturation(SpO_(2))between the two groups before anesthesia(T_(0)),at 10 min after anesthesia administration(T_(4))and 15 min after anesthesia administration(T_(5))(P>0.05).At 1 min(T_(1)),3 min(T_(2))and 5 min(T_(3))after anesthesia administration,SpO_(2) in two groups was lower than that at T_(0),but SpO_(2) in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.001).At T_(0),there was no significant difference in mean arterial pressure(MAP)between the two groups(P>0.05).At T_(1),T_(2),T_(3),T_(4) and T_(5),MAP in two groups was lower than that at T_(0),but MAP in the experimental group was higher than that in the control group,and the difference was statistically sig-nificant(P<0.001).There was no significant difference in heart rate(HR)between the two groups at T_(0),T_(1),T_(2),T_(3) and T_(5)(P>0.05).At T_(4),HR in two groups was lower than that at T_(0),but HR in the experimental group was higher than that in the control group,and the difference was statistically significant(P=0.003).The total incidence of adverse events in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.0

关 键 词：无痛胃肠镜 呼吸抑制 循环抑制 尼可刹米 

分 类 号：R614[医药卫生—麻醉学]