肠道菌群与良性前列腺增生的关系和潜在机制  

Relationship and potential mechanisms between gut microbiota and benign prostatic hyperplasia

作　　者：王聪聪 张洁[3] 郭梦梦 李路遥 曾宪涛 张圆圆 王双瑛 秦长江[1] WANG Congcong;ZHANG Jie;GUO Mengmeng;LI Luyao;ZENG Xiantao;ZHANG Yuanyuan;WANG Shuangying;QIN Changjiang(Department of General Surgery,Huaihe Hospital of Henan University,Kaifeng 475099,Henan province,China;Center for Evidence-Based and Translational Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Administrative Department of Retirement Affairs,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Gongli Hospital of Shanghai Pudong New Area,Shanghai 200135,China;Department of Urology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China)

机构地区：[1]河南大学淮河医院普通外科,河南开封475099 [2]武汉大学中南医院循证与转化医学中心,武汉430071 [3]武汉大学中南医院离退休工作处,武汉430071 [4]上海市浦东新区公利医院泌尿外科,上海200135 [5]武汉大学中南医院泌尿外科,武汉430071

出　　处：《医学新知》2024年第5期582-592,共11页New Medicine

基　　金：国家自然科学基金面上项目(82370778);湖北省自然科学基金杰出青年项目(2023AFA061);中央高校基本科研业务费专项资金(2042023kf0091)。

摘　　要：人体微生物群被定义为栖息在特定人体部分的共生微生物群,其中肠道微生物是人体最庞大的微生物群之一。近年来微生物组的研究为人类健康和疾病提供了新的视角,越来越多的研究表明肠道菌群失调与良性前列腺增生(benign prostatic hyperplasia,BPH)的进展有关。肠道菌群紊乱可能引起局部或全身炎症而影响BPH,由肠道微生物引起的性激素、胰岛素样生长因子1(insulin-like growth factor,IGF-1)等水平改变及代谢综合征(metabolic syndrome,MS)等可能参与BPH发展。此外,衰老及饮食等过程中肠道微生物组成的改变也可能是影响BPH的因素。本文着重于近年来肠道菌群与BPH的研究进展,并探讨肠道微生物如何通过炎症、性激素、IGF-1、MS、衰老和饮食等与BPH相关联,以期从调节肠道菌群的角度为BPH防治提供新思路和新方法。Microbiota is defined as symbiotic microflora living in specific parts of the human body,with the gut microbiota being one of the largest microbiotas in the human body.In recent years,research on the microbiome has provided new perspectives on human health and disease,with increasing evidence suggesting a link between gut microbiota imbalance and the progression of benign prostatic hyperplasia(BPH).Disruption of the gut microbiota may lead to local or systemic inflammation affecting BPH,with changes in levels of sex hormones,insulinlike growth factor 1(IGF-1)induced by gut microbiota,and metabolic syndrome(MS)possibly involved in BPH development.Furthermore,alterations in gut microbiota composition during aging and dietary may also be factors influencing BPH.This article focuses on recent advances in research on the gut microbiota and BPH,exploring how gut microbiota is linked to BPH through inflammation,sex hormones,IGF-1,MS,aging,and diet to provide new perspectives and approaches for the prevention and treatment of BPH by interfering with the gut microbiota.

关 键 词：肠道微生物 良性前列腺增生 性激素 炎症 代谢紊乱 

分 类 号：R697.3[医药卫生—泌尿科学]