抗逆转录病毒疗法对艾滋病病人肠道菌群影响的研究进展  

Research progress on the effect of antiretroviral therapy on the intestinal flora of AIDS patients

作　　者：朱稷蔚 潘文涛 艾克热木·艾尔肯 任皓 马芮雪 伊克拉木·阿布都克日木 卡思木江·阿西木江 ZHU Jiwei;PAN Wentao;AIKEREMU Aierken;REN Hao;MA Ruixue;YIKELAMU Abudoukerimu;KASIMUJIANG Aximujiang(The Fifth Clinical Medical College of Xinjiang Medical University,Urumqi,Xinjiang Uygur Autonomous Region 830017,China;Care Center of Yining Second People's Hospital,Yining,Xinjiang Uygur Autonomous Region 835000,China;Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Xinjiang Medical University,Xinjiang Key Laboratory of Molecular Biology for Endemic Disease,Urumqi,Xinjiang Uygur Autonomous Region 830017,China)

机构地区：[1]新疆医科大学第五临床医学院,新疆维吾尔自治区乌鲁木齐830017 [2]伊宁市第二人民医院关爱中心,新疆维吾尔自治区伊宁835000 [3]新疆医科大学基础医学院生物化学与分子生物学教研室、新疆地方病分子生物学重点实验室,新疆维吾尔自治区乌鲁木齐830017

出　　处：《安徽医药》2024年第6期1061-1065,共5页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金项目(81760754);国家级大学生创新创业训练计划项目(202210760022)。

摘　　要：艾滋病是一种人类免疫缺陷病毒(human immunodeficiency virus,HIV)引起的免疫缺陷疾病,目前普遍通过高效的抗逆转录病毒疗法(antiretroviral treatment,ART)来降低病人病毒载量,延缓艾滋病进程。但由胃肠道菌群引起的消化道疾病、肿瘤等艾滋相关并发症仍然威胁着HIV感染者的生活和健康,同时ART的使用也会导致肠上皮黏膜屏障损伤及肠道免疫异常并肠道菌群平衡的破坏。该研究通过总结分析ART治疗后的艾滋病病人肠道菌群和免疫变化相关的研究,深入了解ART对肠道菌群的影响,为减轻抗逆转录药物对消化道的影响提供新的思路。Acquired immune deficiency syndrome(AIDS)is an immunodeficiency disease caused by human immunodeficiency virus(HIV).Currently,highly effective antiretroviral therapy(ART)is widely used to reduce the viral load of patients and delay the progression of AIDS.However,AIDS-related complications such as digestive diseases and tumors caused by gastrointestinal flora still threaten the life and health of HIV-infected people,and the use of ART also leads to damage of the intestinal epithelial mucosal barrier and abnormal intestinal immunity as well as destruction of the intestinal flora balance.This review summarizes and analyzes studies related to the intestinal flora and immune changes in HIV patients after ART treatment to gain insight into the effects of ART on the intestinal flora and to provide new ideas for mitigating the effects of antiretroviral drugs on the digestive tract.

关 键 词：获得性免疫缺陷综合征 抗逆转录病毒疗法 肠道菌群 免疫调节 人类免疫缺陷病毒 

分 类 号：R512.91[医药卫生—内科学]