面向先进生物医学应用的光声显微成像术(特邀)  

Photoacoustic Microscopy Imaging for Advanced Biomedical Applications(Invited)

作　　者：马海钢 吴家辉 朱亚辉 魏翔 于音什 任世利 陈钱 左超[1,2,3] Ma Haigang;Wu Jiahui;Zhu Yahui;Wei Xiang;Yu Yinshi;Ren Shili;Chen Qian;Zuo Chao(Smart Computational Imaging Laboratory(SCILab),School of Electronic and Optical Engineering,Nanjing University of Science and Technology,Nanjing 210094,Jiangsu,China;Jiangsu Key Laboratory of Spectral Imaging and Intelligence Sense,Nanjing University of Science and Technology,Nanjing 210094,Jiangsu,China;Smart Computational Imaging Research Institute(SCIRI),Nanjing University of Science and Technology,Nanjing 210019,Jiangsu,China)

机构地区：[1]南京理工大学电子工程与光电技术学院智能计算成像实验室(SCILab),江苏南京210094 [2]南京理工大学江苏省光谱成像与智能感知重点实验室,江苏南京210094 [3]南京理工大学智能计算成像研究院(SCIRI),江苏南京210019

出　　处：《激光与光电子学进展》2024年第6期105-134,共30页Laser & Optoelectronics Progress

基　　金：国家自然科学基金(62275121,12204239);国家重大科研仪器研制项目(62227818);国家重点研发计划(2022YFB2804600,2022YFB2804603);江苏省自然科学基金(BK20220946);中央高校基本科研业务费专项资金资助(30923011024)。

摘　　要：光声显微成像(PAM)是一种具有无损、多功能、高分辨率等特点的生物医学成像技术,通过检测光声信号进行图像重建可实现高分辨率和高深度的结构和功能成像,在生命科学、基础医学和医疗诊断中发挥着越来越重要的作用。首先概述光声显微技术的发展背景和原理特点,然后对利用光学增强、声学增强、人工智能增强及光学与声学互补的光声显微成像术促进成像性能提升的方法进行论述,最后讨论当前光声显微技术在生物医学研究中的广泛应用,并对未来技术的发展趋势进行展望。Photoacoustic microscopy(PAM)is a noninvasive imaging technique that has undergone remarkable advancements and applications in the field of life sciences,basic medical research,and medical diagnostics.It operates on the unique principles of detecting photoacoustic signals and reconstructing them to create high-resolution,in-depth structural and functional images.This paper offers a comprehensive overview of the developmental background and unique principles behind photoacoustic microscopy.As we delve deeper,we explored various methods that have been employed to boost imaging performance.These include,but are not limited to,optical enhancement,acoustic enhancement,exploitation of artificial intelligence to augment the entire process.Moreover,there has been a significant focus on the harmonious integration of optics and acoustics in PAM.Ultimately,we discussed the extensive applications of current PAM in modern biomedical research and provided insights into the future developmental trends of this technique.

关 键 词：生物医学影像 光声显微成像 高分辨 多功能 无损 

分 类 号：O436[机械工程—光学工程]