Wittig反应实验的绿色化改进  

The Greening Improvement of Wittig Reaction Experiment

作　　者：刘宇芳[1] 张彩红[1] 袁茂森[2] LIU Yu-Fang;ZHANG Cai-Hong;YUAN Mao-Sen(School of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China;Northwest A&F University,Yangling 712100,China)

机构地区：[1]山西大学化学化工学院,太原030006 [2]西北农林科技大学,杨凌712100

出　　处：《应用化学》2024年第4期586-592,共7页Chinese Journal of Applied Chemistry

基　　金：山西省高等学校教学改革创新项目(No.J20220069)资助。

摘　　要：传统的有机化学实验教学中,大多侧重实验技能的训练,设置实验内容时对实验安全性、经典性和可重复性等因素考虑较多,而对反应的绿色化、新方法和新技能等重视程度不够。为此,经典的有机反应也需要不断改进,本文将需要在大量有机溶剂中进行的传统Wittig反应改进为无溶剂的固相研磨反应,使得合成方法更加简单、绿色、安全和高效。设计合成了3个不同推拉型(D-π-A)二苯乙烯结构分子,优化了反应条件,测定了它们的光谱性质,并对其进行比较,讨论其构性关系,不仅引入绿色化学理念,而且对知识进行扩展,增加了实验的新颖性、探索性和趣味性,提升了学生创新能力。In the traditional teaching of organic chemistry experimental courses,the teachers usually focus on the training of experimental skills and the investigation of factors such as the safety,canonicity and repeatability of the experiment,while paying insufficient attention to the green factors such as the economy of the reaction,the treatment of by-products and the amount of solvent usage.Besides,the assimilation of new knowledge for organic chemistry and new experimental skills is also seriously lagging behind.Therefore,the new methods and skills of organic synthesis in scientific research are introduced into the experimental teaching of organic chemistry,and the traditional Wittig reaction performing in a large number of organic solvents is modified into a solid phase grinding reaction without solvent,which makes the synthesis method greener,safer and more efficient.Three different styrene molecules with push-pull(D-π-A)structure are designed and synthesized,the reaction conditions are optimized,their spectral properties are compared,and their constitutive relationships are discussed,which not only introduces the concept of green chemistry,but also expands the knowledge,increases the novelty,exploratory and interestingness of the experiment,and enhances students'innovative ability.

关 键 词：绿色化学 WITTIG反应 固相研磨合成 构性分析 基础有机化学实验 

分 类 号：O621.3[理学—有机化学]