桂枝甘草汤加味治疗室性早搏心肾阳虚证患者的临床疗效分析  

Analysis of clinical effect of modified Guizhi Gancao decoction on ventricular premature beat patients with heart-kidney Yang deficiency syndrome

作　　者：王娥 WANG E(Department of Cardiology,Dandong Hospital of Traditional Chinese Medicine,Dandong 118000,China)

机构地区：[1]丹东市中医院心血管病科,118000

出　　处：《中国现代药物应用》2024年第9期127-130,共4页Chinese Journal of Modern Drug Application

摘　　要：目的评估桂枝甘草汤加味治疗室性早搏心肾阳虚证患者的效果。方法58例室性早搏心肾阳虚证患者,随机分为观察组和对照组,各29例。对照组给予胺碘酮治疗,观察组在对照组基础上给予自拟桂枝甘草汤加味治疗。比较两组临床疗效及治疗后心率变异性(HRV)指标[全部窦性R-R间期的标准差(SDNN)、每5分钟窦性R-R间期均值的标准差(SDANN)、每5分钟窦性R-R间期标准差平均值(SDNNI)、正常相邻R-R间期差值>50 ms的百分比(PNN50)]、心功能指标[左室射血分数(LVEF)、左心室短轴缩短率(LVFS)、每搏输出量(SV)及B型脑钠肽(BNP)]、生活质量评分。结果治疗后,观察组总有效率89.7%显著高于对照组的65.5%,差异有统计学意义(P<0.05)。治疗后,观察组SDNN(118.92±13.72)ms、SDANN(114.82±12.96)ms、SDNNI(47.02±5.86)ms、PNN50(9.33±0.94)%、SV(79.92±8.87)ml、LVFS(25.07±2.76)%、LVEF(50.02±5.96)%及BNP(239.281±20.93)ng/L均显著优于对照组的(103.53±11.64)ms、(101.63±10.14)ms、(39.93±4.96)ms、(6.11±0.72)%、(73.33±8.42)ml、(21.83±2.34)%、(45.23±5.74)%、(386.71±36.71)ng/L,差异有统计学意义(P<0.05)。治疗后,观察组身体健康、心理状态、社会功能、日常生活能力评分均显著优于对照组,差异有统计学意义(P<0.05)。结论通过桂枝甘草汤加味治疗室性早搏心肾阳虚证患者,可以显著降低心率变异性,改善患者心功能,提高患者生活质量,疗效确切,可以在临床推广使用。Objective To evaluate the effect of modified Guizhi Gancao decoction on ventricular premature beat patients with heart-kidney Yang deficiency syndrome.Methods 58 cases of ventricular premature beat patients with heart-kidney Yang deficiency syndrome were randomly divided into an observation group and a control group,with 29 cases in each group.The control group was treated with amiodarone,and the observation group was treated with modified Guizhi Gancao decoction on the basis of the control group.Both groups were compared in terms of clinical efficacy and heart rate variability(HRV)index[standard deviation of normal RR intervals(SDNN),standard deviation of per 5 min averages normal number of interval(SDANN),mean of the 5 minute standard deviations for the normal RR intervals(SDNNI),percentage of R-R intervals at least 50 ms different from the previous interval(PNN50)],cardiac function indicators[left ventricular ejection fraction(LVEF),left ventricular fractional shortening(LVFS),stroke volume(SV)and B-type brain natriuretic peptide(BNP)],quality of life score after treatment.Results After treatment,the total effective rate of the observation group was 89.7%,which was significantly higher than 65.5% of the control group,and the difference was statistically significant(P<0.05).After treatment,the observation group had SDNN of(118.92±13.72)ms,SDANN of(114.82±12.96)ms,SDNNI of(47.02±5.86)ms,PN50 of(9.33±0.94)%,SV of(79.92±8.87)ml,LVFS of(25.07±2.76)%,LVEF of(50.02±5.96)% and BNP of(239.281±20.93)ng/L,which were significantly better than(103.53±11.64)ms,(101.63±10.14)ms,(39.93±4.96)ms,(6.11±0.72)%,(73.33±8.42)ml,(21.83±2.34)%,(45.23±5.74)%and(386.71±36.71)ng/L in the control group.The difference was statistically significant(P<0.05).After treatment,the scores of physical health,psychological state,social function and daily living ability of the observation group were significantly better than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Modified Guizhi

关 键 词：室性早搏 心肾阳虚证 桂枝甘草汤 胺碘酮 心率变异性 

分 类 号：R259[医药卫生—中西医结合]