嗜麦芽窄食单胞菌耐药率变化与抗菌药物使用强度的相关性分析  

Correlation between drug-resistant rates of Stenotrophomonas maltophilia and antimicrobial use density

作　　者：辛红梅 牛慧云[1] 刘晓燕[2] 赵文渊 徐凤英 XIN Hong-mei;NIU Hui-yun;LIU Xiao-yan(The Third Affiliated Hospital of Baotou Medical College,Baotou 014030,China)

机构地区：[1]包头医学院第三附属医院,014030 [2]包头市肿瘤医院,014030

出　　处：《中国现代药物应用》2024年第9期155-158,共4页Chinese Journal of Modern Drug Application

基　　金：包头医学院科研基金项目青苗计划(项目编号:byjj-gyqm002)。

摘　　要：目的分析嗜麦芽窄食单胞菌的耐药率变化与抗菌药物使用强度之间的相关性。方法统计某三级医院2018~2022年住院患者的嗜麦芽窄食单胞菌的临床分布、耐药率和常用抗菌药物使用强度,采用Spearman进行相关性分析。结果药敏检出438株嗜麦芽窄食单胞菌,其对米诺环素、复方新诺明、左氧氟沙星和氯霉素的耐药率较低,分别为2.19%、7.84%、11.00%和17.59%,对头孢他啶的耐药率相对较高,为36.30%。嗜麦芽窄食单胞菌对头孢他啶的耐药率与碳氢霉希类抗菌药物使用强度呈正相关(r=0.880,P<0.05)。结论抗菌药物使用强度可影响嗜麦芽窄食单胞菌对部分抗菌药物的耐药率,合理控制抗菌药物使用、降低使用强度可减少嗜麦芽窄食单胞菌的诱导耐药。Objective To analyze the correlation between drug-resistant rates of Stenotrophomonas maltophilia and antimicrobial use density.Methods The clinical distribution,drug-resist rate and use intensity of common antibiotics of Stenotrophomonas maltophilia in hospitalized patients in a tertiary hospital from 2018 to 2022 were analyzed and Spearman correlation analysis was used.Results Drug sensitivity test showed 438 strains of Stenotrophomonas maltophilia,and they had low resistance to minocycline,compound sulfamethoxazole,levofloxacin and chloramphenicol,which were 2.19%,7.84%,11.00%and 17.59%,and relatively high drug-resistance rate to ceftazidime of 36.30%.The drug-resistant rate of Stenotrophomonas maltophilia to ceftazidime was positively correlated with the intensity of use of carbapenem antibiotics(r=0.880,P<0.05).Conclusion The antimicrobial use density can affect the resistance rate of Stenotrophomonas maltophilia to some antibiotics.The antimicrobial use density can affect the resistance rate of Stenotrophomonas maltophilia to some antibiotics.Reasonable control and reduction of the intensity of use of antibiotics can reduce the induced resistance of Stenotrophomonas maltophilia.

关 键 词：嗜麦芽窄食单胞菌 耐药率 使用强度 相关性 

分 类 号：R446.5[医药卫生—诊断学]