氟比洛芬酯复合利多卡因用于妇科腹腔镜手术的麻醉效果研究  

Anesthetic Effects of Flurbiprofen Axetil Combined with Lidocaine in Patients Undergoing Gynecological Laparoscopic Surgery

作　　者：卓婷婷 肖丽 马超 向睿[3] ZHUO Tingting;XIAO Li;MA Chao;XIANG Rui(Dept.of Anesthesiology,Sichuan Mianyang 404 Hospital,Sichuan Mianyang 621000,China;Dept.of Critical Care Medicine,Sichuan Mianyang 404 Hospital,Sichuan Mianyang 621000,China;Dept.of Obstetrics and Gynecology,the Second Affiliated Hospital of Nuclear Industry 416,Chengdu Medical College,Chengdu 610000,China)

机构地区：[1]四川绵阳四〇四医院麻醉科,四川绵阳621000 [2]四川绵阳四〇四医院重症医学科,四川绵阳621000 [3]成都医学院第二附属·核工业四一六医院妇产科,成都610000

出　　处：《中国医院用药评价与分析》2024年第5期541-544,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：四川省卫生健康委员会科研项目(No.19PJ211)。

摘　　要：目的:探讨氟比洛芬酯复合利多卡因用于妇科腹腔镜手术的麻醉效果。方法:选取2020年10月至2022年10月于四川绵阳四〇四医院择期行腹腔镜手术的132例患者,采用单双号法分为对照组和联合组,各66例。麻醉诱导前10 min,对照组患者静脉注射0.9%氯化钠注射液10 mL,联合组患者双通道泵入氟比洛芬酯1.0 mg/kg+利多卡因1.0 mg/kg,术中持续输注利多卡因1.0 mg/(kg·h)至手术结束。比较两组患者术中用药剂量、脑电双频指数,术后(4、6和12 h)镇痛质量,术后12 h血清应激反应指标[肾上腺素(E)、去甲肾上腺素(NE)和皮质醇(Cor)]水平及术后24 h内不良反应发生情况。结果:联合组患者瑞芬太尼、丙泊酚总用量显著低于对照组;联合组患者插管前1 min、插管后1 min及插管后5 min的脑电双频指数显著低于对照组;术后4、6和12 h,联合组患者疼痛程度评分显著低于对照组,舒适度评分显著高于对照组;术后12 h,两组患者E、NE及Cor水平均较术前显著升高,但联合组患者的E、NE及Cor水平显著低于对照组,上述差异均有统计学意义(P<0.05)。术后24 h内,联合组、对照组患者的不良反应总发生率分别为4.55%(3/66)、7.58%(5/66),差异无统计学意义(P>0.05)。结论:氟比洛芬酯复合利多卡因预防性镇痛可有效提高妇科腹腔镜手术患者的麻醉镇痛质量,减轻机体围手术期应激反应,且使用安全。OBJECTIVE:To probe into the anesthetic effects of flurbiprofen axetil combined with lidocaine in patients undergoing gynecological laparoscopic surgery.METHODS:Totally 132 patients undergoing gynecological laparoscopic surgery in Sichuan Mianyang 404 Hospital from Oct.2020 to Oct.2022 were extracted to be divided into the control group and combined group by the odd-even number method,with 66 cases in each group.The control group was intravenously injected with 10 mL 0.9%sodium chloride injection at 10 min before anesthesia induction,while the combined group was pumped with flurbiprofen axetil 1.0 mg/kg+lidocaine 1.0 mg/kg through double channels,with a continuous intraoperative infusion of lidocaine 1.0 mg/(kg·h)until the end of surgery.The intraoperative drug dosage,intraoperative bispectral indicator,analgesia quality after surgery of 4 h,6 h and 12 h,levels of serum stress response indicators[epinephrine(E),norepinephrine(NE),cortisol(Cor)]after surgery of 12 h and occurrence of adverse drug reactions within 24 h after surgery were compared between two groups.RESULTS:The total dosage of remifentanil and propofol in combined group was significantly lower than that in control group;(P<0.05).the bispectral index in combined group was significantly lower than that in control group at 1 min before intubation,at 1 min after intubation and at 5 min after intubation;(P<0.05).the pain scores in combined group after surgery of 4 h,6 h and 12 h were significantly lower than those in control group(P<0.05),while the comfort scores were significantly higher than those in control group;(P<0.05).after surgery of 12 h,the levels of E,NE and Cor increased significantly in two groups compared with those before surgery,(P<0.05),yet the combined group was lower than the control group,with statistically significant differences(P<0.05).Within 24 h after surgery,the total incidence of adverse drug reactions in combined group and control group was respectively 4.55%(3/66)and 7.58%(5/66),with no statistically significant difference(P>

关 键 词：氟比洛芬酯 利多卡因 腹腔镜手术 预防性镇痛 镇痛质量 应激反应 

分 类 号：R971.2[医药卫生—药品]