CRP/PCT比值对社区获得性肺炎患者早期治疗的价值  

Value of CRP/PCT Ratio in Early Treatment of Community-Acquired Pneumonia Patients

作　　者：倪春艳 刘斐烨 NI Chunyan;LIU Feiye(Dept.of Pharmacy,the Third Affiliated Hospital of Soochow University/the First People’s Hospital of Changzhou,Jiangsu Changzhou 213003,China)

机构地区：[1]苏州大学附属第三医院/常州市第一人民医院药学部,江苏常州213003

出　　处：《中国医院用药评价与分析》2024年第5期560-562,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：常州市科技计划项目(No.CJ20219026)。

摘　　要：目的:评价C反应蛋白(CRP)/降钙素原(PCT)比值在社区获得性肺炎患者抗菌药物选择中的应用价值。方法:选取2022年该院收治的79例经CRP/PCT比值干预用药的社区获得性肺炎患者作为干预组,另选取同期该院收治的121例社区获得性肺炎患者作为对照组。比较两组患者的临床治疗效果。结果:统计CRP/PCT比值指导用药后,与对照组相应病原体组相比,干预组典型病原体组患者的住院时间缩短,次均费用降低(P<0.05);干预组非典型病原体组患者的住院时间显著缩短,次均费用显著降低(P<0.01),差异均有统计学意义。与对照组非典型病原体组相比,干预组非典型病原体组患者β-内酰胺类抗菌药物使用率、次均药费显著降低,初始抗菌药物治疗方案有效率明显改善,差异均有统计学意义(P<0.01)。两组患者不良反应发生率、30 d复发率的差异均无统计学意义(P>0.05)。结论:对于社区获得性肺炎患者,CRP/PCT比值能够作为一种快捷的早期选择抗菌药物的依据。OBJECTIVE:To evaluate the application value of C-reactive proten(CRP)/procalcitonin(PCT)ratio in the selection of antibiotics for community-acquired pneumonia patients.METHODS:In 2022,79 patients with community-acquired pneumonia treated with CRP/PCT ratio intervention medication were extracted as the intervention group,and 121 patients with community-acquired pneumonia treated in the hospital during the same period were selected as the control group.The clinical treatment effects of two groups were compared.RESULTS:After CRP/PCT ratio intervention medication,compared with the corresponding pathogen in the control group,the duration of length of stay in the intervention group with typical pathogen was shorter and the average cost per visit was lower(P<0.05);in the intervention group with atypical pathogen,the length of stay was significantly shortened,and the average cost per visit decreased significantly(P<0.01),with statistically significant differences.Compared with atypical pathogen pathogen in the control group,the application rate ofβ-lactam antibiotics and average cost per visit in atypical pathogen of the intervention group decreased significantly,and the effective rate of the initial antibiotic therapy was significantly improved,with statistically significant differences(P<0.01).There were no significant differences in the incidence of adverse drug reactions and 30 d recurrence between two groups(P>0.05).CONCLUSIONS:For patients with community-acquired pneumonia,the CRP/PCT ratio can be used as a quick basis for early selection of antibiotics.

关 键 词：社区获得性肺炎 典型病原体 非典型病原体 C反应蛋白/降钙素原比值 

分 类 号：R978.1[医药卫生—药品] R974[医药卫生—药学]