附子理中汤联合足三里穴位注射配合循经热熨法对腹腔镜胃癌术后(脾胃虚寒证)患者胃肠激素、炎症反应、营养参数和血清MIP-3α、Stathmin的影响  

Effects of Fuzi Lizhong Decoction Combined with Zusanli Injection and Heat Ironing on Gastrointestinal Hormones,Inflammatory Response,Nutritional Parameters,Serum MIP-3α and Stathmin of Patients After Laparoscopic Gastric Cancer Surgery(Spleen-Stomach Deficiency Cold Syndrome)

作　　者：唐焕峰[1] 袁大为 王华 吕炳涛 秦利民[1] TANG Huanfeng;YUAN Dawei;WANG Hua;LYU Bingtao;QIN Limin(Dept.of Surgery,Qinhuangdao Hospital of Traditional Chinese Medicine,Hebei Qinhuangdao 066000,China)

机构地区：[1]秦皇岛市中医医院外科,河北秦皇岛066000

出　　处：《中国医院用药评价与分析》2024年第5期563-566,570,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河北省医学重点科技攻关计划项目(No.2020YS0329);秦皇岛市科学技术研究与发展计划项目(No.202101A071)。

摘　　要：目的:观察附子理中汤联合足三里穴位注射配合循经热熨法对腹腔镜胃癌术后(脾胃虚寒证)患者胃肠激素、炎症反应、营养参数和血清微管解聚蛋白(Stathmin)、巨噬细胞炎性蛋白-3α(MIP-3α)的影响。方法:选择2021年1月至2023年3月该院收治的胃癌患者126例,分组方式为随机数字表法。对照组42例患者(脱落2例,最终纳入40例)给予常规西医治疗,观察1组42例患者(脱落3例,最终纳入39例)在对照组的基础上给予足三里穴位注射配合循经热熨法治疗,观察2组42例患者(脱落2例,最终纳入40例)在观察1组的基础上给予附子理中汤治疗。比较三组患者的临床疗效,记录肛门首次排气时间、首次经口进食时间和首次排便时间;术后1、15 d测定三组患者营养参数(血清血红蛋白、转铁蛋白和白蛋白),检测炎症反应指标[血红素加氧酶-1(HO-1)、缺氧诱导因子-1α(HIF-1α)和白细胞介素6(IL-6)]、胃肠激素指标[胃泌素17(G-17)、胃动素(MTL)]及MIP-3α、Stathmin水平。结果:观察1组、观察2组患者的总有效率分别为94.87%(37/39)、97.50%(39/40),高于对照组的75.00%(30/40),差异有统计学意义(P<0.05);而观察2组与观察1组患者总有效率的差异无统计学意义(P>0.05)。观察2组患者肛门首次排气时间、首次经口进食时间和首次排便时间短于对照组、观察1组,且观察1组患者短于对照组,差异均有统计学意义(P<0.05)。术后15 d,观察2组患者转铁蛋白、血红蛋白和白蛋白水平高于对照组、观察1组,且观察1组患者高于对照组;观察2组患者HO-1、HIF-1α和IL-6水平低于对照组、观察1组,且观察1组患者低于对照组;观察2组患者G-17、MTL水平高于对照组、观察1组,且观察1组患者高于对照组;观察2组患者Stathmin、MIP-3α水平低于对照组、观察1组,且观察1组患者低于对照组,上述差异均有统计学意义(P<0.05)。结论:附子理中汤联合足三里穴位注射配合循OBJECTIVE:To observe the effects of Fuzi Lizhong decoction combined with Zusanli injection and heat ironing on gastrointestinal hormones,inflammatory response,nutritional parameters,serum microtubule depolymerizing protein(Stathmin)and macrophage inflammatory protein-3α(MIP-3α)in patients after laparoscopic gastric cancer surgery(spleen-stomach deficiency cold syndrome).METHODS:A total of 126 patients with gastric cancer admitted into the hospital from Jan.2021 to Mar.2023 were selected and grouped by random number table method.In the control group,42 patients(2 cases dropped,40 cases eventually enrolled)were given conventional Western medicine treatment,and 42 patients(3 cases dropped,39 cases eventually enrolled)in the observation group 1 were treated with Zusanli injection combined with heat ironing therapy based on the control group,42 patients(2 cases dropped,40 cases eventually enrolled)in the observation group 2 received Fuzi Lizhong decoction on the basis of the observation group 1.The clinical efficacy of three groups was compared,and the time of first anal exhaust,first oral feeding and first defecation were recorded in three groups.Nutritional parameters(serum hemoglobin,transferrin and albumin)on the 1 d and 15 d after surgery,the inflammatory response indicators[heme oxygenase-1(HO-1),hypoxia-inducing factor-1(HIF-1α)and interleukin-6(IL-6)],gastrointestinal hormone indicators[gastrin 17(G-17),motilin(MTL)],MIP-3αand Stathmin levels of three groups were detected.RESULTS:The total effective rate of observation group 1 and observation group 2 was respectively 94.87%(37/39)and 97.50%(39/40),higher than that 75.00%(30/40)of control group,the difference was statistically significant(P<0.05).There was no significant difference in the total effective rate between observation group 2 and observation group 1(P>0.05).The time of first anal exhaust,first oral feeding and first defecation in observation group 2 was shorter than that in control group and observation group 1,and observation group 1 was shorter

关 键 词：附子理中汤 足三里穴位注射 循经热熨法 腹腔镜胃癌术 炎症反应 胃肠激素 营养参数 

分 类 号：R932[医药卫生—生药学]