齐拉西酮对精神分裂症患者认知功能和生活质量的治疗效果研究  

Effects of Ziprasidone on Cognitive Function and Quality of Life in Patients with Schizophrenia

作　　者：陈赢 何其华[2] 陆由虎 CHEN Ying;HE Qihua;LU Youhu(The 6th Ward,Anqing Psychiatric Hospital,Anhui Anqing 246003,China;the 3rd Ward,Anqing Psychiatric Hospital,Anhui Anqing 246003,China)

机构地区：[1]安庆市精神病医院六病区,安徽安庆246003 [2]安庆市精神病医院三病区,安徽安庆246003

出　　处：《中国医院用药评价与分析》2024年第5期571-573,581,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨齐拉西酮对精神分裂症患者认知功能和生活质量的影响。方法:选择2022年1月至2023年1月该院收治的精神分裂症患者110例作为研究对象,采用随机数字表法分为对照组和观察组,各55例。对照组患者给予利培酮治疗,观察组患者给予齐拉西酮治疗,两组患者均连续治疗8周,治疗期间不使用其他抗精神病药。比较两组患者的临床疗效、简易精神状态检查量表(MMSE)评分、精神分裂症患者生活质量量表(SQLS)评分及不良反应发生情况。结果:观察组、对照组患者的总有效率相近[83.64%(46/55)vs. 89.09%(49/55)],差异无统计学意义(P>0.05)。观察组患者治疗后的MMSE量表评分(定向力评分、即刻记忆评分、延时记忆评分、注意力及计算力评分和语言及视空间能力评分)高于对照组,SQLS量表评分(中心理社会分量表评分、动机/精力分量表评分和症状/不良反应分量表评分)低于对照组,差异均有统计学意义(P<0.05)。观察组患者的不良反应发生率为5.45%(3/55),低于对照组的18.18%(10/55),差异有统计学意义(P<0.05)。结论:齐拉西酮与利培酮治疗精神分裂症的临床疗效相近,但齐拉西酮对认知功能和生活质量的改善效果更为显著,且安全性更高。OBJECTIVE:To probe into the effects of ziprasidone on cognitive function and quality of life in patients with schizophrenia.METHODS:A total of 110 patients with schizophrenia admitted into the hospital from Jan.2022 to Jan.2023 were extracted to be divided into the control group and observation group via the random number table method,with 55 cases in each group.The control group was treated with risperidone,while the observation group received ziprasidone.Both groups were treated for 8 weeks without using other antipsychotic drugs during the treatment period.The clinical efficacy,mini mental status examination(MMSE)score,quality of life scale score(SQLS)and adverse drug reactions of two groups were compared.RESULTS:The total effective rate of observation group and control group was similar[83.64%(46/55)vs.89.09%(49/55)],with no statistically significant difference(P>0.05).After treatment,MMSE scores(orientation score,immediate memory score,delayed memory score,attention and computational power,and language and visuospatial ability score)in observation group were higher than those in control group,while SQLS scores(medium psychosocial scale,motivation/energy scale and symptom/adverse drug reaction scale)were lower than those in control group,the differences were statistically significant(P<0.05).The incidence of adverse drug reactions in observation group was 5.45%(3/55),lower than 18.18%(10/55)in control group,the difference was statistically significant(P<0.05).CONCLUSIONS:The clinical efficacy of ziprasidone and risperidone in the treatment of schizophrenia is similar,yet ziprasidone has more significant effect on improving cognitive function and quality of life,and has higher safety.

关 键 词：精神分裂症 齐拉西酮 利培酮 认知功能 生活质量 

分 类 号：R971.41[医药卫生—药品]