抗磷脂酰丝氨酸-凝血酶原复合物抗体在抗磷脂综合征患者中的诊断价值  

Diagnostic value of anti-phosphatidylserine-prothrombin complex antibodies in patients with antiphospholipid syndrome

作　　者：徐进 张莹 王晓芳 李梓来 王悦 何巧花 XU Jin;ZHANG Ying;WANG Xiao-fang;LI Zi-lai;WANG Yue(Center for Reproductive Medicine,Henan Provincial People’s Hospital,People’s Hospital of Zhengzhou University,Zhengzhou 450003,China)

机构地区：[1]郑州大学人民医院,河南省人民医院生殖中心,郑州450003

出　　处：《医药论坛杂志》2024年第8期802-805,810,共5页Journal of Medical Forum

基　　金：河南省医学科技攻关计划省部共建项目(SBGJ202302013)。

摘　　要：目的研究抗磷脂酰丝氨酸-凝血酶原复合物抗体(aPS/PT)在血清阴性抗磷脂综合征(SN-APS)患者中的诊断价值。方法入选2023年4月至2023年9月来河南省人民医院就诊患者,将研究对象分为健康对照组、抗磷脂综合征(APS)组和SN-APS组,采用磁微粒化学发光法检测标准抗磷脂抗体和aPS/PT,计算各抗磷脂抗体百分位值并评估aPS/PT诊断价值。结果aCL和aβ2GP I-IgA/IgM/IgG的P99分别为5.52、19.81、20.22 IU/mL和21.16、25.38、19.30 IU/mL,P97.5分别为4.77、18.89、16.35 IU/mL和20.20、16.90、18.18 IU/mL,P95分别为3.22、14.99、8.61 IU/mL和7.49、5.04、6.95 IU/mL。aPS/PT-IgM/IgG的P99分别为19.72、20.96 IU/mL,aPS/PT-IgM/IgG的P97.5分别为18.84、20.7 IU/mL,aPS/PT-IgM/IgG的P95分别为18.36、17.24 IU/mL。SN-APS组的aPS/PT-IgM水平高于健康对照组,以17.26 IU/mL为截断值时,诊断敏感性为29.73%,特异性为93.33%。结论本研究建立了实验室内部标准抗磷脂抗体和aPS/PT的参考区间,并发现aPS/PT-IgM对SN-APS患者有一定的诊断价值。Objective This study aimed to evaluate the diagnostic value of anti-phosphatidylserine-prothrombin complex antibody(aPS/PT)in patients with seronegative antiphospholipid syndrome(SN-APS).Methods Consecutive enrollment was conducted for patients who visited Henan Provincial People's Hospital from April 2023 to September 2023.The study subjects were divided into a healthy control group,an antiphospholipid syndrome(APS)group,and an SN-APS group.The magnetic particle chemiluminescence method was used to detect standard anti-phospholipid antibodies and aPS/PT.Percentile values were calculated for each anti-phospholipid antibody,and the diagnostic value of aPS/PT was evaluated.Results The P99 values for aCL and aβ2GP I-IgA/IgM/IgG were 5.52,19.81,20.22 IU/mL and 21.16,25.38,19.30 IU/mL respectively;P 97.5 values were 4.77,18.89,16.35 IU/mL and 20.20,16.90,18.18 IU/mL respectively;P95 values were 3.22,14.99,8.61 IU/mL and 7.49,5.04,6.95 IU/mL respectively.The P99 values for aPS/PT-IgM/IgG were 19.72 and 20.96 IU/mL and the P97.5 values were 18.84 and 20.7 IU/mL,respectively.The P95 values for aPS/PT-IgM/IgG were 18.36 and 17.24 IU/mL,respectively.The level of aPS/PT-IgM was higher in the SN-APS group than in the healthy control group.When using a cutoff value of 17.26 IU/mL,the diagnostic sensitivity was 29.73%and the specificity was 93.33%.Conclusion This study established reference intervals for laboratory standard anti-phospholipid antibodies and aPS/PT while also finding that aPS/PT-IgM has certain diagnostic value in SN-APS patients.

关 键 词：抗磷脂酰丝氨酸-凝血酶原复合物抗体 抗磷脂综合征 诊断价值 

分 类 号：R446.1[医药卫生—诊断学]