医用三氧大自血疗法联合双氯芬酸钠治疗急性痛风性关节炎患者的疗效及安全性  

Efficacy and safety of medical oxygen trioxide autohemotherapy combined with diclofenac sodium in treatment of patients with acute gouty arthritis

作　　者：魏艳林 赵曼 桂银莉 李陶冉 王旭[1] 常琼洁 王静[1] 郇稳 刘志队 韩丹 郑利萍 赵雪品 陈运转 WEI Yan-lin;ZHAO Man;GUI Yin-li;LI Tao-ran;WANG XU;CHANG Qiong-jie;WANG Jing;HUAN Wen;LIU Zhi-dui;HAN Dan;ZHENG Li-ping;ZHAO Xue-pin;CHEN Yun-zhuan(Department of Rheumatology and Immunology,the Fifth Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou People's Hospital,Zhengzhou 450003,China)

机构地区：[1]河南中医药大学第五临床医学院,郑州人民医院风湿免疫科,郑州450003

出　　处：《医药论坛杂志》2024年第8期806-810,共5页Journal of Medical Forum

基　　金：河南省科技攻关项目(232102310163)。

摘　　要：目的探讨医用三氧大自血疗法联合双氯芬酸钠治疗急性痛风性关节炎(AGA)患者的疗效及安全性。方法选取郑州人民医院2022年6月至2023年6月收治的126例AGA患者为研究对象。采用随机数字表法将患者分为双氯芬酸钠组(双氯芬酸钠治疗)和医用三氧组(三氧大自血联合双氯芬酸钠治疗),各63例。治疗1周后,比较两组临床疗效、关节疼痛、肿胀、活动受限评分、血沉、血清TNF-α、IL-6、IL-1β、CRP水平及不良反应。结果治疗1周后,医用三氧组治疗总有效率为96.83%,明显高于双氯芬酸钠组的79.37%(P<0.05);医用三氧组关节疼痛、肿胀、活动受限评分明显低于双氯芬酸钠组(P<0.05);血沉、血清TNF-α、IL-6、IL-1β、CRP水平明显低于双氯芬酸钠组(P<0.05);治疗期间,医用三氧组不良反应发生率为12.67%,略高于双氯芬酸钠组的9.52%,但组间比较,无显著性差异(P>0.05)。结论采用医用三氧大自血疗法联合双氯芬酸钠治疗AGA患者具有较高的临床疗效,可有效减轻关节疼痛、肿胀程度,改善患者关节活动受限,降低血沉,减轻炎性反应,且未显著增加不良反应,具有较高的安全性。Objective To explore the efficacy and safety of medical oxygen trioxide autohemotherapy combined with diclofenac sodium in the treatment of patients with acute gouty arthritis(AGA).Methods Totally 126 AGA patients admitted to Zhengzhou People's Hospital from June 2022 to June 2023 were selected as the study subjects.The patients were randomly divided into diclofenac sodium group(treated with diclofenac sodium)and medical oxygen trioxide group(treated with medical oxygen trioxide autohemotherapy and diclofenac sodium),with 63 cases in each group.After 1 week of treatment,the clinical efficacy,joint pain,swelling,limited mobility score,erythrocyte sedimentation rate,TNF-α,IL-6,IL-1βCRP levels,and adverse reactions were compared between the two groups.Results After 1 week of treatment,the total effective rate of medical oxygen trioxide group was 96.83%,which was significantly higher than that of diclofenac sodium group 79.37%(P<0.05);The scores of joint pain,swelling and activity limitation in the medical oxygen trioxide group were significantly lower than those in the diclofenac sodium group(P<0.05);Erythrocyte sedimentation rate,TNF-α,IL-6,IL-1β,CRP levels were significantly lower than those in the diclofenac sodium group(P<0.05);During the treatment,the incidence of adverse reactions in the medical oxygen trioxide group was 12.67%,which was slightly higher than that in the diclofenac sodium group(9.52%),but the difference was not significant between the groups(P>0.05).Conclusion The medical oxygen trioxide autohemotherapy combined with diclofenac sodium in treatment of AGA patients has a higher clinical efficacy,which can effectively reduce the degree of joint pain and swelling,improve the patients'limited joint movement,reduce the erythrocyte sedimentation rate,reduce inflammatory reaction,and does not significantly increase adverse reactions,with a higher safety.

关 键 词：急性痛风性关节炎 医用三氧大自血疗法 双氯芬酸钠 

分 类 号：R589.7[医药卫生—内分泌]