替加环素诱发严重中毒性表皮松解症致死亡1例  

Death due to severe toxic epidermal necrolysis induced by tigecycline:a case report

作　　者：李相军 徐珊珊[2] 汤建军 LI Xiangjun;XU Shanshan;TANG Jianjun(Department of Neurology,Shanghai Deji Hospital(Qingdao University,Shanghai Neuromedical Center),Shanghai 200333,China;Department of Pharmacy,Shanghai Deji Hospital(Qingdao University,Shanghai Neuromedical Center),Shanghai 200333,China)

机构地区：[1]上海德济医院(青岛大学上海临床医学院)神经内科,上海200333 [2]上海德济医院(青岛大学上海临床医学院)药剂科,上海200333

出　　处：《中国药师》2024年第4期722-728,共7页China Pharmacist

摘　　要：本文通过1例高龄患者应用替加环素后出现中毒性表皮松解症(TEN)的案例,结合国内外文献资料进行分析讨论。根据药物不良反应关联性评价标准,该患者出现的TEN与替加环素关联性较大。提示临床医师和药师在临床工作中需警惕和重视替加环素可能引起的中毒性表皮坏死松解症。In this paper,a case of toxic epidermal necrolysis(TEN)after application of tigecycline in an elderly patient was analyzed,and was analyzed and discussed combined with domestic and foreign literature.According to the criteria for assessing the association of adverse drug reactions,the TEN present in this patient is likely to be related to tigecycline.It is suggested that clinicians and pharmacists should be vigilant and pay attention to TEN that may be caused by tigecycline in clinical work.

关 键 词：中毒性表皮坏死松解症 替加环素 药品不良反应 

分 类 号：R969[医药卫生—药理学]