Bcl-2和GPER在子宫内膜息肉患者组织中的表达及相关性分析  

Analysis on the expressions and correlation of Bcl-2 and GPER in tissues of patients with endometrial polyp

作　　者：王潇洒[1] 张静[1] 盛理超[1] 鲁波[1] WANG Xiao-sa;ZHANG Jing;SHENG Li-chao;LU Bo(Shaoxing Municipal Maternal and Child Health Care Hospital,Shaoxing,Zhejiang 312000,China)

机构地区：[1]绍兴市妇幼保健院,浙江绍兴312000

出　　处：《中国妇幼保健》2024年第9期1686-1689,共4页Maternal and Child Health Care of China

基　　金：浙江省医药卫生科技计划项目(2019KY719)。

摘　　要：目的 分析B细胞淋巴瘤/白血病-2(Bcl-2)和G蛋白耦联雌激素受体(GPER)在子宫内膜息肉患者组织中的表达及相关性,为临床诊治提供参考。方法 选取2010年10月—2012年4月绍兴市妇幼保健院收治的子宫内膜息肉患者30例为研究组,正常子宫内膜的30例患者为对照组。使用免疫组化Envision法检测Bcl-2、GPER阳性率,分析二者的相关性。结果 Bcl-2在研究组和对照组的阳性率分别为66.67%和26.67%,研究组的阳性率高于对照组,差异有统计学意义(χ^(2)=10.545,P<0.05)。Bcl-2在研究组增生期和分泌期的阳性率分别为68.75%和64.29%,差异无统计学意义(P>0.05)。Bcl-2在对照组增生期和分泌期的阳性率分别为43.75%和7.14%,增生期的阳性率高于分泌期,差异有统计学意义(P<0.05)。GPER在研究组和对照组的阳性率分别为73.33%和16.67%,研究组的阳性率高于对照组,差异有统计学意义(P<0.05)。GPER在对照组增生期与分泌期的阳性率分别为18.75%和14.29%,差异无统计学意义(P>0.05)。GPER在研究组增生期和分泌期的阳性率分别为56.25%和92.86%,分泌期的阳性率高于增生期,差异有统计学意义(P<0.05)。Spearman相关性分析结果表明:Bcl-2与GPER在子宫内膜息肉患者中的表达呈正相关(r_s=0.933,0.872,均P<0.05)。结论 Bcl-2和GPER高表达使子宫内膜息肉组织凋亡减弱、增生加强,进而导致子宫内膜息肉的发生,并促进其发展。Objective To analyze the expressions and correlation of B cell lymphoma/leukemia-2(Bcl-2) and G protein-coupled estrogen receptor(GPER) in tissues of patients with endometrial polyp, provide a reference for clinical diagnosis and treatment.Methods A total of 30 patients with endometrial polyp treated in Shaoxing Municipal Maternal and Child Health Care Hospital from October 2010 to April 2012 were selected as study group, 30 patients with normal endometrium were selected as control group.Immunohistochemical Envision method was used to detect the positive rates of Bcl-2 and GPER, the correlation between Bcl-2 and GPER was analyzed.Results The positive rates of Bcl-2 in study group and control group were 66.67% and 26.67%, respectively, the positive rate in study group was statistically significantly higher than that in control group(χ^(2)=10.545,P<0.05).The positive rates of Bcl-2 during proliferative stage and secretory phase in study group were 68.75% and 64.29%, respectively, there was no statistically significant difference between the two groups(P>0.05).The positive rates of Bcl-2 during proliferative stage and secretory phase in control group were 43.75% and 7.14%, respectively, the positive rate during proliferative stage was statistically significantly higher than that during secretory phase(P<0.05).The positive rates of GPER in study group and control group were 73.33% and 16.67%, respectively, the positive rate in study group was statistically significantly higher than that in control group(P<0.05).The positive rates of GPER during proliferative stage and secretory phase in control group were 18.75% and 14.29%, there was no statistically significant difference between the two groups(P>0.05).The positive rates of GPER during proliferative stage and secretory phase in study group were 56.25% and 92.86%, respectively, the positive rate during secretory phase was statistically significantly higher than that during proliferative stage(P<0.05).Spearman correlation analysis showed that Bcl-2 was positively cor

关 键 词：子宫内膜息肉 G蛋白耦联雌激素受体 B细胞淋巴瘤/白血病-2 相关性 

分 类 号：R711.74[医药卫生—妇产科学]