环泊酚与异丙酚在纤维支气管镜检查中的有效性和安全性对比  

Comparison of the Efficacy and Safety of Propofol and Propofol During Fiberoptic Bronchoscopy

作　　者：朱文超[1] 吴滨 王庆贺 任春光[1] 赵静[1] ZHU Wenchao;WU Bin;WANG Qinghe;REN Chunguang;ZHAO Jing(Department of Anaesthesiology,Liaocheng People's Hospital,Shandong Province,Liaocheng Shandong 252000,China)

机构地区：[1]山东省聊城市人民医院麻醉科,山东聊城252000

出　　处：《中国卫生标准管理》2024年第9期154-157,共4页China Health Standard Management

基　　金：2022年度山东省医学会镇痛镇静-麻醉优化科研专项资金项目(YXH2022ZX05278)。

摘　　要：目的比较接受纤维支气管镜检查的患者使用环泊酚与异丙酚的有效性和安全性。方法选取2023年3—6月在山东省聊城市人民医院接受纤维支气管镜检查的92例患者,随机数字表法均分为环泊酚组和异丙酚组。主要观察指标是纤维支气管镜检查的成功率,次要结果包括人口统计学特征、时间指标、血流动力学、咳嗽严重程度、插管条件、最低氧饱和度、患者和内镜医生的满意度评分、患者重复纤维支气管镜检查意愿以及不良事件的发生率。结果与异丙酚组相比,环泊酚组患者时间指标差异无统计学意义(P>0.05);重复纤维支气管镜检查的意愿、血流动力学、最低氧饱和度以及患者和内镜医生的满意度显著提高(P<0.05)。环泊酚组纤维支气管镜检查成功完成率为91.30%(42/46,95%CI 82.80%~99.80%),异丙酚组纤维支气管镜检查成功完成率为89.13%(41/46,95%CI 79.80%~98.50%)。2组纤维支气管镜检查成功完成率的差异为2.17%(95%CI 1.30%~3.00%)。因此,在接受纤维支气管镜检查的患者中,环泊酚组被认为不劣于异丙酚组(χ^(2)=0.123,P>0.05)。结论环泊酚组患者在纤维支气管镜检查中的有效性不低于丙泊酚组,同时,患者重复纤维支气管镜检查的意愿和满意度均显著提高。Objective To compare the efficacy and safety of ciprofol versus propofol for patients undergoing fiberoptic bronchoscopy.Methods A total of 92 patients undergoing fiberoptic bronchoscopy at Liaocheng People's Hospital,Shandong Province from March to June 2023 were equally divided into the ciprofol group and propofol group.The primary outcome was the successful rate of fiberoptic bronchoscopy.Secondary outcomes included demographic characteristics,time metrics,hemodynamics,coughing severity,intubating conditions,lowest oxygen saturation,satisfaction scores of both patients and the endoscopist,patients'willing to repeat fiberoptic bronchoscopy,and occurrence of adverse events.Results There was no statistically significant difference in time indicators between the two groups(P>0.05).Compared with the propofol group,the willingness to repeat fiberoptic bronchoscopy,hemodynamics,lowest oxygen saturation,and satisfaction of patients and endoscopists were significantly improved in the ciprofol group(P<0.05).The success rate of fiberoptic bronchoscopy in the propofol group was 91.30%(42/46,95%CI 82.80% to 99.80%),while the success rate of fiberoptic bronchoscopy in the propofol group was 89.13%(41/46,95%CI 79.80% to 98.50%).The difference in successful completion rates between the two groups of fiberoptic bronchoscopy examinations is 2.17%(95%CI:1.30%to 3.00%).Therefore,among patients undergoing fiberoptic bronchoscopy,the group treated with propofol was considered not inferior to the group treated with propofol(χ^(2)=0.123,P>0.05).Conclusion Ciprofol was noninferior to propofol with regard to successful sedation for flexible bronchoscopy.At the same time,patients'willingness to repeat flexible bronchoscopy and the satisfactions were all significantly improved.

关 键 词：环泊酚 异丙酚 纤维支气管镜 瑞芬太尼 芬太尼 舒适化医疗 

分 类 号：R521[医药卫生—内科学]