巨噬细胞极化在矽肺纤维化中的研究进展  

Research progress of macrophage polarization in silicosis fibrosis

作　　者：彭方达 代静 丁春光 Peng Fangda;Dai Jing;Ding Chunguang(Center of Occupational Hazards Evidence Analysis,National Center for Occupational Safety and Health,NHC,Beijing 102308,China)

机构地区：[1]国家卫生健康委职业安全卫生研究中心职业危害物证分析中心,北京102308

出　　处：《中华劳动卫生职业病杂志》2024年第4期315-320,共6页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家卫健委职业安全卫生研究中心自管项目(2019009)。

摘　　要：矽肺是一种常见的职业病,其主要病理特征以硅结节的形成和弥漫性肺纤维化为主。在矽肺纤维化过程中巨噬细胞可极化为M1型巨噬细胞和M2型巨噬细胞。M1型巨噬细胞在矽肺早期发挥促炎作用释放多种炎症因子,是炎症反应的核心。M2型巨噬细胞通过分泌抗炎细胞因子和促纤维化介质在矽肺纤维化阶段促进炎症消退和组织修复。M1/M2极化平衡对矽肺的发生发展起着重要作用,调控巨噬细胞极化方向可能对矽肺纤维化的预防和治疗起到积极作用。本文主要对巨噬细胞极化在矽肺纤维化中的作用,矽肺纤维化中调控巨噬细胞极化的相关信号通路,以及矽肺纤维化中基于巨噬细胞极化的潜在治疗靶点进行综述,以期进一步加强对巨噬细胞极化在矽肺纤维化发病和治疗中有关机制的了解。Silicosis is a common occupational disease,and its main characteristic pathological features are the formation of silicon nodules and diffuse pulmonary fibrosis.In the process of silicosis fibrosis,macrophages can be polarized into M1 macrophages and M2 macrophages.M1 macrophages play a pro-inflammatory role in the early stage of silicosis and release a variety of inflammatory factors,which is the core of inflammatory response.M2 macrophages promote inflammation resolution and tissue repair in silicosis fibrosis stage by secreting anti-inflammatory cytokines and pro-fibrotic mediators.M1/M2 polarization balance plays an important role in the occurrence and development of silicosis,and the regulation of macrophage polarization direction may play a positive role in the prevention and treatment of silicosis fibrosis.In this review,the role of macrophage polarization in silicosis fibrosis,the related signaling pathways regulating macrophage polarization in silicosis fibrosis,and the potential therapeutic targets based on macrophage polarization in silicosis fibrosis are reviewed,with a view to further strengthening the understanding of the mechanism of macrophage polarization in the pathogenesis and treatment of silicosis fibrosis.

关 键 词：矽肺 职业病 肺纤维化 巨噬细胞 极化 信号通路 

分 类 号：R135.2[医药卫生—劳动卫生]