冠心病患者外周血HOXA4基因表达及心血管病危险因素与冠心病病变特点的分析  

Correlation between HOXA4 gene expression in peripheral blood in patients with coronary heart disease and cardiovascular risk factors and characteristics of coronary artery lesions

作　　者：莫睿 吴强[1] 周瑜 龙向淑[1] MO Rui;WU Qiang;ZHOU Yu;LONG Xiangshu(Department of Cardiology,Guizhou Province People's Hospital,Guiyang,550002,China)

机构地区：[1]贵州省人民医院心内科,贵阳550002

出　　处：《临床心血管病杂志》2024年第4期291-295,共5页Journal of Clinical Cardiology

基　　金：贵州省卫生健康委科学技术基金项目(No:gzwkj2021-113)。

摘　　要：目的:分析冠心病(CHD)患者外周血中同源框A4基因(HOXA4)表达及心血管病危险因素与CHD病变特点的相关性。方法:纳入2021年11月1日—2022年1月31日连续在我院心脏介入中心行冠状动脉造影(CAG)的患者395例,其中确诊CHD 295例(A组),排除CHD 100例(B组)。据CAG结果将A组分为2个亚组,即中度狭窄组(A1亚组)和重度狭窄组(A2亚组)。CAG前收集外周动脉血3 mL检测HOXA4 mRNA表达并记录患者血糖、血压及血脂等心血管病危险因素。比较组间HOXA4表达差异,逻辑回归分析HOXA4、心血管病危险因素与CHD病变特点的相关性。结果:HOXA4在A组和A2亚组的表达低于B组(P<0.05)。HOXA4及高密度脂蛋白胆固醇(HDL-C)与CHD呈负相关(Adjusted OR<1,P<0.05),年龄、吸烟、高血压及糖尿病与CHD呈正相关(Adjusted OR>1,P<0.05)。以B组为对照,HOXA4表达、HDL-C水平与冠脉中、重狭窄呈负相关(Adjusted OR<1,P<0.05);增龄与冠脉中、重度狭窄呈正相关(Adjusted OR>1,P<0.05);吸烟、糖尿病与冠脉重度狭窄呈正相关(Adjusted OR>1,P<0.05);高血压与冠脉中度狭窄呈正相关(Adjusted OR>1,P<0.05)。结论:HOXA4低表达、低水平HDL-C、增龄、吸烟、高血压及糖尿病是CHD的危险因素,其中HOXA4低表达、低水平HDL-C及增龄与冠脉中、重度狭窄相关,吸烟、糖尿病与冠脉重度狭窄相关,而高血压与冠脉中度狭窄相关。Objective To analyze the expression of homeobox A4 gene(HOXA4)in peripheral blood of patients with coronary heart disease(CHD)and the correlation between cardiovascular risk factors and characteristics of coronary artery lesions.Methods The 395 patients who underwent continuous coronary angiography in the Cardiac Intervention Center in our Hospital from November 01,2021 to January 31,2022 were selected.Among them,295 patients were diagnosed definitely with CHD by CAG(Group A),and 100 patients without CHD(Group B).According to the results of CAG,Group A were divided into two subgroups:moderate stenosis group(Subgroup A1)and severe stenosis group(Subgroup A2).The 3 mL arterial blood was extracted from peripheral arteries before CAG to detect the mRNA expression of HOXA4 and recording clinical risk factors such as blood glucose,blood pressure,and lipids of the patient.The difference of HOXA4 expression between each groups was compared by non-parametric test,and the correlation between HOXA4,cardiovascular risk factors and characteristics of coronary artery lesions was analyzed by logistic regression.Results The expression of HOXA4 in Group A and Subgroup A2 were lower than that in Group B(P<0.05).HOXA4 and HDL-C were negatively correlated with CHD(Adjusted OR<1,P<0.05),age,smoking,hypertension and diabetes were positively correlated with CHD(Adjusted OR>1,P<0.05).Compared with Group B,the expression of HOXA4 and HDL-C level were negatively correlated with moderate and severe coronary artery stenosis(Adjusted OR<1,P<0.05).There was a positive correlation between aging and moderate and severe coronary artery stenosis(Adjusted OR>1,P<0.05).Smoking and diabetes were positively correlated with severe coronary artery stenosis(Adjusted OR>1,P<0.05).Hypertension was positively correlated with moderate coronary artery stenosis(Adjusted OR>1,P<0.05).Conclusion Low expression of HOXA4,low level of HDL-C,aging,smoking,hypertension and diabetes were the risk factors of CHD,among which low expression of HOXA4,low level of HDL-C a

关 键 词：同源框A4基因 心血管病危险因素 冠心病 冠状动脉狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]