纳米载体用于内耳靶向递送的研究进展  

Research progress in targeted delivery of inner ear using nanocarriers

作　　者：陈耀恒 张宏征[1] CHEN Yaoheng;ZHANG Hongzheng(Department of Otolaryngology Head and Neck Surgery,Affiliated Zhujiang Hospital of Southern Medical University,Department of Southern Medical University Hearing Research Center,Guangzhou,510220,China)

机构地区：[1]南方医科大学珠江医院耳鼻咽喉头颈外科中心、南方医科大学听力研究中心,广州510220

出　　处：《临床耳鼻咽喉头颈外科杂志》2024年第4期348-353,共6页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金面上项目(No:82271156);广东省基础与应用基础研究基金项目(No:2022A1515012036)。

摘　　要：感音神经性聋、梅尼埃病等各种内耳疾病给患者带来言语交流障碍、工作效率下降等问题,严重影响患者生活质量。内耳存在特殊的解剖结构及血-迷路屏障,目前常用的给药方式往往无法取得令人满意的疗效。纳米载体是目前纳米科技研究的前沿和热点,近年在内耳靶向递送领域取得了不少研究进展,有望最终应用于临床内耳疾病的治疗。本文着重介绍各种纳米载体在内耳靶向递送方面的优势、主要研究成果和局限性进行综述,希望为相关研究提供新的思路。Various inner ear diseases such as sensorineural deafness and Meniere's disease bring about problems such as speech communication disorders and decreased work efficiency,which seriously affect the life quality of patients.Due to the special anatomical structure and blood-labyrinth barrier in the inner ear,the current drug administration methods are often unable to achieve satisfactory results.Nanocarriers are the forefront and hot spot of nanotechnology research.In recent years,a lot of research progress has been made in the field of targeted delivery of the inner ear,which is expected to be eventually applied to the treatment of clinical diseases of the inner ear.This review focuses on the advantages,main research achievements and limitations of various nanocarriers in the targeted delivery of the inner ear,hoping to provide new ideas for related research.

关 键 词：纳米载体 感音神经性聋 内耳 靶向给药 基因治疗 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]