“肠道菌群—细胞焦亡”与溃疡性结肠炎“浊毒内蕴”病因病机  

Etiology and Pathogenesis of"Gut Microbiota-Pyroptosis"and"Turbid Toxin Internalization"in Ulcerative Colitis

作　　者：贾雪梅 郭榆西 王杰 马虹宇 才艳茹 赵丹阳 杜朋丽 杜姚[1,2] 李博林 杨倩[1,2] JIA Xue-mei;GUO Yu-xi;WANG Jie;MA Hong-yu;CAI Yan-ru;ZHAO Dan-yang;DU Peng-li;DU Yao;LI Bo-lin;YANG Qian(Department of Spleen and Stomach Diseases,Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang,050011;Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Gastrointestinal Diseases,Shijiazhuang,050011)

机构地区：[1]河北省中医院脾胃病科,石家庄050011 [2]河北省中西医结合胃肠病研究重点实验室,石家庄050011

出　　处：《中国中西医结合杂志》2024年第4期475-480,共6页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家中医临床研究基地建设项目(国中医药办科技函[2018]131号);国家科技部重点研发课题(No.2018YFC1704102);河北省中医药管理局科研计划项目(No.2020079,No.2020080,No.2020083,No.2022032)。

摘　　要：肠道菌群与细胞焦亡互作失衡与溃疡性结肠炎的发病密切相关,浊毒内蕴是溃疡性结肠炎发病的关键病机。结合现代分子生物学及中医学理论研究,笔者认为肠道菌群紊乱是浊毒内蕴的病理学基础,细胞焦亡为浊毒内蕴的微观体现,在溃疡性结肠炎发病过程中,“肠道菌群—细胞焦亡”互作紊乱与溃疡性结肠炎“浊毒内蕴”病机相契合。本文从“肠道菌群—细胞焦亡”互作失衡角度探讨“浊毒内蕴”的病因病机,是将现代分子生物学与中医学理论相结合的初步尝试,旨在为临床防治溃疡性结肠炎提供新思路和突破点。The imbalance in the interaction between gut microbiota and pyroptosis is closely related to the incidence of ulcerative colitis(Uc)."Turbid toxin internalization"is the key pathogenesis of UC.According to modern molecular biology and the classical theory of Chinese medicine(CM),the authors proposed that the disorder of gut microbiota is the pathological basis of turbid toxin internalization,and pyroptosis is the microscopic embodiment of turbid toxin internalization.In UC,the core pathogenesis of"turbid toxin internalization"is the same as the imbalanced relationships in"gut microbiota-pyroptosis."In this article,the authors discussed the etiology and pathogenesis of"turbid toxin internalization"in ulcerative colitis from the perspective of imbalanced relationships between gut microbiota and pyroptosis,which was aimed at providing new ideas and breakthrough points for clinical prevention and treatment of UC.

关 键 词：肠道菌群 细胞焦亡 溃疡性结肠炎 浊毒内蕴 科学内涵 中西医结合 

分 类 号：R259[医药卫生—中西医结合]