Diabetes and pulmonary infection:how hyperglycaemia shapes the immune system  

作　　者：Christian Herder Michael Roden Nicolas Venteclef 

机构地区：[1]Institute for Clinical Diabetology,German Diabetes Center,Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf,40225,Düsseldorf,Germany [2]German Center for Diabetes Research(DZD),Partner Düsseldorf,85764,München-Neuherberg,Germany [3]Department of Endocrinology and Diabetology,Medical Faculty and University Hospital Düsseldorf,Heinrich Heine University Düsseldorf,40225,Düsseldorf,Germany [4]Institut Necker-Enfants Malades(INEM),UniversitéParis Cité,INSERM UMR-S1151,CNRS UMR-S8253,Paris,France

出　　处：《Signal Transduction and Targeted Therapy》2024年第4期1245-1246,共2页信号转导与靶向治疗（英文）

基　　金：supported by a grant from Horizon Europe (INTERCEPT-T2D,101095433);supported by the German Diabetes Center (DDZ),which is funded by the German Federal Ministry of Health (Berlin,Germany);the Ministry of Culture and Science of the state North Rhine-Westphalia (Düsseldorf,Germany);receives additional funding from the German Federal Ministry of Education and Research (BMBF)through the German Center for Diabetes Research (DZD e.V.).

摘　　要：In a recent study published in Nature,Nobs and colleagues aimed to identify novel mechanisms that may explain why diabetes is associated with an increased susceptibility to viral respiratory infections.Their analyses revealed a central role of lung dendritic cells(DC)which exhibited several functional defects induced by hyperglycaemia and consequently result in impaired antiviral immune responses.

关 键 词：IMPAIRED LUNG RESPIRATORY 

分 类 号：R587.1[医药卫生—内分泌] R563[医药卫生—内科学]