血清α-HBDH和ApoB水平对合并MVD的AMI患者PCI术后3年内MACE发生的预测价值  

The value ofα-HBDH and ApoB in predicting MACE occurrence within 3years after PCI in AMI patients with MVD

作　　者：蔡蕊 商婷婷 周琳 王翠平[1] 袁伟[1] CAI Rui;SHANG Tingting;ZHOU Lin(Department of Cardiology,Affiliated Hospital of Jiangsu University,Zhenjiang 212001,CHINA)

机构地区：[1]江苏大学附属医院心血管内科,江苏镇江212001

出　　处：《江苏医药》2024年第4期334-337,共4页Jiangsu Medical Journal

基　　金：江苏省卫生健康委员会基金(H2018004);江苏省青年医学重点人才培养基金(QNRC2016837)。

摘　　要：目的探讨血清α羟丁酸脱氢酶(α-HBDH)和载脂蛋白B(ApoB)水平对合并多支血管病变(MVD)的急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后3年内主要不良心血管事件(MACE)发生的预测价值。方法合并MVD的AMI患者108例行PCI治疗,根据3年随访结果分为A组(发生MACE,33例)和B组(未发生MACE,75例)。比较两组实验室血液指标及左心室射血分数,采用多因素logistic回归分析合并MVD的AMI患者PCI术后3年内MACE发生的影响因素,绘制ROC曲线分析血清α-HBDH和ApoB水平对合并MVD的AMI患者PCI术后3年内MACE发生的预测效能。结果A组血清α-HBDH和ApoB水平高于B组(P<0.05)。血清α-HBDH和ApoB水平升高是AMI合并MVD患者PCI术后MACE发生的独立危险因素(P<0.05)。血清α-HBDH和ApoB水平对合并MVD的AMI患者PCI术后3年内MACE发生具有良好的预测效能(P<0.05),联合检测的灵敏度更高。结论血清α-HBDH和ApoB水平可用于预测AMI合并MVD患者PCI术后3年内MACE的发生。Objective To explore the value ofα-hydroxybutyrate dehydrogenase(α-HBDH)and apolipoprotein B(ApoB)in predicting major adverse cardiovascular events(MACE)occurrence within 3years after percutaneous coronary intervention(PCI)in acute myocardial infarction(AMI)patients with multivessel disease(MVD).Methods A total of 108 AMI patients with MVD underwent PCI were divided into groups of A(33cases with MACE)and B(75cases without MACE)according to 3-year follow-up results.The baseline clinical data of two groups were compared.Multivariate logistic regression was used to analyze the influencing factors for MACE occurrence after PCI in AMI patients with MVD,and ROC curve was drawn to analyze the predictive efficacy of serum levels ofα-HBDH and ApoB on MACE occurrence after PCI in AMI patients with MVD.Results Serum levels ofα-HBDH and ApoB in group A were higher than those in group B(P<0.05).The increased serum levels ofα-HBDH and ApoB were the independent risk factors for MACE occurrence in AMI patients with MVD after PCI(P<0.05).Serum level ofα-HBDH or ApoB had better predictive value for MACE occurrence after PCI in AMI patients with MVD(P<0.05).The sensitivity was higher in combination of them thanα-HBDH or ApoB alone.Conclusion Serum levels ofα-HBDH and ApoB can be used to predict MACE occurrence after PCI in AMI patients with MVD.

关 键 词：α羟丁酸脱氢酶 载脂蛋白B 急性心肌梗死 多支血管病变 经皮冠状动脉介入治疗 

分 类 号：R541[医药卫生—心血管疾病]