产褥期阴道炎患者病原菌分布及药敏情况分析  

Pathogenic Bacteria Distribution and Drug Sensitivity Analysis of Puerperal Vaginitis

作　　者：常超 高立娟 范晓丽 王向红 CHANG Chao;GAO Lijuan;FAN Xiaoli;WANG Xianghong(Department of Obstetrics and Gynecology,General Hospital of Pingdingshan Pingmei Shenma Medical Group,Pingdingshan 467000,Henan,China)

机构地区：[1]平顶山市平煤神马医疗集团总医院妇产科,河南平顶山467000

出　　处：《中国药物滥用防治杂志》2024年第4期644-647,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨产褥期阴道炎患者病原菌分布和药敏情况。方法:选取2018年5月—2022年6月在本院产科发生产褥期阴道炎的141例产妇患者作为研究对象,均采集阴道分泌物进行病原菌培养及药敏试验。结果:共分离出209株病原菌,其中细菌204株占97.61%,真菌5株占2.39%;主要革兰阳性菌中溶血性链球菌、金黄色葡萄球菌、表皮葡萄球菌对青霉素、红霉素、四环素、头孢唑林、头孢西林、环丙沙星耐药性较高(63.04%~96.97%),对左氧氟沙星耐药性稍低(46.67%~13.04%),对亚胺培南、利奈唑胺、万古霉素无耐药性;主要革兰阴性菌中大肠埃希菌、肺炎克雷伯菌对氨苄西林、头孢唑林、头孢他啶、哌拉西林、庆大霉素具有较高的耐药性(43.48%~95.65%),对左氧氟沙星、环丙沙星、头孢哌酮耐药性偏低(43.75%~13.04%),对阿米卡星、替拉考宁、亚胺培南具有低耐药性或无耐药性(6.25%~0)。结论:产褥期阴道炎患者病原菌以细菌为主,且对多数抗生素具有一定耐药性,临床应根据药敏结果结合用药安全性合理选择抗菌药物进行治疗。Objective:To explore the distribution and drug sensitivity of pathogenic bacteria in puerperal vaginitis patients.Methods:A total of 141 parturients with puerperal vaginitis in our obstetrics department from May 2018 to June 2022 were selected as the study subjects,and the vaginal secretions were collected for pathogenic bacteria culture and drug sensitivity test.Results:Totally 209 strains of pathogenic bacteria were isolated,of which 204 strains of bacteria accounted for 97.61%,and 5 strains of fungi accounted for 2.39%.Among the main gram-positive bacteria,Streptococcus haemolyticus,Staphylococcus aureus and Staphylococcus epidermidis had high resistance to penicillin,erythromycin,tetracycline,cefazolin,cefocillin and ciprofloxacin(63.04%-96.97%),and they had slightly low resistance to levofoxacin(46.67%-13.04%),and no resistance to imipenem,linezolid and vancomycin.Among the main gram-negative bacteria,Escherichia coli and Klebsiella pneumoniae had high resistance to ampicillin,cefazolin,ceftazidime,piperacillin and gentamicin(43.48%-95.65%),low resistance to levofloxacin,ciprofloxacin and cefoperazone(43.75%-13.04%),and low or no resistance to amikacin,tiraconin and imipenem(6.25%-0).Conclusion:The pathogenic bacteria of puerperal vaginitis patients are mainly bacteria,and they are resistant to most antibiotics to a certain extent.Therefore,we should reasonably choose antibiotics for treatment according to the drug sensitivity results and drug safety.

关 键 词：产褥期 阴道炎 病原菌 药敏试验 

分 类 号：R446.5[医药卫生—诊断学] R714.62[医药卫生—临床医学]