AZT+EFV/NVP用药治疗方案预防艾滋病母婴传播的效果分析  

Analysis of the Effect of AZT+EFV/NVP Drug Treatment Scheme on Preventing Mother-infant Transmission of AIDS

作　　者：孙冉 史晓林[2] 贾玉珍 SUN Ran;SHI Xiaolin;JIA Yuzhen(AIDS Prevention and Control Department,Zhenping County Center for Disease Control and Prevention,Zhenping 474250,Henan,China;Department of Laboratory Medicine,Nanyang Center for Disease Control and Prevention,Nanyang 473001,Henan,China;Department of Pediatrics,the First Afliated Hospital of Nanyang Medical College,Nanyang 473007,Henan,China)

机构地区：[1]河南省镇平县疾病预防控制中心艾滋病防治科,河南镇平474250 [2]南阳市疾病预防控制中心检验科,河南南阳473001 [3]南阳医专第一附属医院儿科,河南南阳473007

出　　处：《中国药物滥用防治杂志》2024年第4期707-710,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨AZT+EFV/NVP用药治疗方案预防艾滋病(HIV)母婴传播的效果。方法:选取2018年5月—2023年1月河南省镇平县疾病预防控制中心诊治的艾滋病孕妇86例作为研究对象,根据1∶1随机硬币抽签法将患者分为观察组43例与传统组43例。观察组给予AZT+EFV/NVP用药治疗,传统组给予AZT+3TC+LPV/r用药治疗,比较新生儿HIV阳性情况。结果:所有孕妇都顺利完成分娩,孕妇与新生儿都存活;观察组新生儿HIV阳性率、HIV载量低于传统组,CD4^(+)T淋巴细胞计数水平高于传统组(P<0.05)。观察组皮疹、头晕、贫血不良反应发生率低于传统组(P<0.05)。结论:AZT+EFV/NVP用药治疗方案可预防艾滋病母婴传播的发生,提高孕妇CD4^(+)T淋巴细胞计数水平,降低HIV病毒载量,且可降低孕妇并发症发生率。Objective:To explore the efect of AZT+EFV/NVP drug therapy on preventing mother-infant transmission of AIDS(HIV).Methods:A total of 86 pregnant women with AIDS diagnosed and treated by the Zhenping County Center for Disease Control and Prevention,Henan Province,from May 2018 to January 2023 were selected as the study subjects.According to the 1:1 random coin draw method,the patients were divided into the observation group of 43 cases and the traditional group of 43 cases.The observation group was treated with AZT+EFV/NVP medication,while the traditional group was treated with AZT+3TC+LPV/r medication,the HIV positive status of newborns were compared between the two groups.Results:All pregnant women successfully completed delivery,pregnant women and newborns were alive;the HIV positive rate and HIV load of newborns in the observation group were lower than those in the traditional group,and the CD4^(+)T lymphocyte count level was higher than that in the traditional group(P<0.05).The incidence of adverse reactions such as rash,dizziness and anemia in the observation group was lower than that in the traditional group(P<0.05).Conclusion:AZT+EFV/NVP drug treatment program can prevent mother-infant transmission of AIDS,improve the CD4^(+)T lymphocyte count,reduce HIV viral load,and reduce the incidence of complications in pregnant women.

关 键 词：AZT+EFV/NVP用药治疗方案 AZT+3TC+LPV/r用药方案 CD4^(+)T淋巴细胞计数 病毒载量 艾滋病 母婴传播 

分 类 号：R714.251[医药卫生—妇产科学]