糖皮质激素雾化吸入联合阿奇霉素序贯疗法治疗重症MPP患儿的效果  

Effect of Glucocorticoid Aerosol Inhalation Combined with Azithromycin Sequential Therapy in the Treatment of Children with Severe MPP

作　　者：吴克诚 陈翔[2] WU Kecheng;CHEN Xiang(The Third Afliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang,China;The Second Afliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang,China)

机构地区：[1]温州医科大学附属第三医院,浙江温州325000 [2]温州医科大学附属第二医院,浙江温州325000

出　　处：《中国药物滥用防治杂志》2024年第4期725-729,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：温州市科研项目(编号:Y2023310)。

摘　　要：目的:分析重症肺炎支原体肺炎(SMPP)患儿应用糖皮质激素雾化吸入联合阿奇霉素序贯疗法治疗的临床效果。方法:选择我院2022年1月—2023年12月期间收治的SMPP患儿70例为研究对象,根据随机数字表法将其分为单一组与联合组,每组35例。单一组给予阿奇霉素序贯疗法治疗,联合组在单一组的基础上加用糖皮质激素(布地奈德)治疗。比较两组临床疗效、症状消失消失时间、淋巴因子、炎症因子、不良反应发生情况。结果:联合组总有效率高于单一组(P<0.05);联合组高热、咳嗽、呼吸困难、肺部湿啰音、胸片阴影消失时间短于单一组(P<0.05);两组治疗1周后白细胞介素-6、白细胞介素-10、C反应蛋白、降钙素原水平低于治疗前,且联合组低于单一组(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:应用糖皮质激素联合阿奇霉素序贯疗法治疗可有效提高对SMPP患儿的治疗效果,缓解其病情症状,调节免疫炎症反应,且无明显严重不良反应发生。Objective:To analyze the clinical efect of glucocorticoid aerosol inhalation combined with azithromycin sequential therapy in children with severe mycoplasma pneumoniae pneumonia(SMPP).Methods:A total of 70 children with SMPP admitted to our hospital from January 2022 to December 2023 were selected as the research objects.According to the random number method,they were divided into single group and combined group,with 35 cases in each group.The single group was treated with azithromycin sequential therapy,and the combined group was treated with glucocorticoid(budesonide)on the basis of the single group.The clinical efficacy,disappearance time of symptoms,lymph factors,inflammatory factors and adverse reactions were compared between the two groups.Results:The total efective rate of the combined group was higher than that of the single group(P<0.05).The disappearance time of high fever,cough,dyspnea,lung moist rale and chest X-ray shadow in the combined group was shorter than that in the single group(P<0.05).After 1 week of treatment,the levels of interleukin-6,interleukin-10,C-reactive protein and procalcitonin in the two groups were lower than those before treatment,and those in the combined group were lower than those in the single group(P<0.05).There was no signifcant diference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:The sequential therapy of glucocorticoid combined with azithromycin can efectively improve the therapeutic efect on children with SMPP,relieve the symptoms of the disease,regulate the immune infammatory response,and have no obvious serious adverse reactions.

关 键 词：重症肺炎支原体肺炎 阿奇霉素 糖皮质激素 序贯疗法 

分 类 号：R725.6[医药卫生—儿科]