儿童功能性便秘古今用药规律对比分析  

Comparative Analysis of Ancient and Modern Chinese Medicinal Prescriptions in the Treatment of Children Functional Constipation

作　　者：杨宇琳 李惠芳 王君[2] 刘小琪 YANG Yulin;LI Huifang;WANG Jun;LIU Xiaoqi(Beijing University of Chinese Medicine,Beijing 100029,China;China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029 [2]中日友好医院,北京100029

出　　处：《辽宁中医药大学学报》2024年第6期98-102,F0003,共6页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家重点研发计划项目(2018YFC1704100,2018YFC1704105)。

摘　　要：目的对比分析古今中医治疗儿童功能性便秘(functional constipation,FC)的用药规律,为中医药治疗儿童FC提供新思路。方法收集并整理《中华医典》、中国知网、万方、维普、中国生物医学文献数据库中治疗儿童FC的内服方剂,分别建立古今方药数据库。借助中医传承计算平台对处方中的药物进行频次统计、关联规则及聚类分析。结果共纳入古方206首、药物149味,性味以苦寒为主,功效以泻下、理气为主。常用药对为郁李仁-大黄与芒硝-大黄。共纳入今方89首、药物107味,性味以甘温为主,功效以补虚、理气为主。常用药对为甘草、枳实-火麻仁。古今药物归经均以脾经、胃经、肺经、大肠经为主,涉及心经、肝经、肾经。均得到3对核心药物组合。结论古今医家均注重理气以恢复大肠传导功能,古方偏重泻实,今方偏重补虚。Objective To explore and compare the medication rules of traditional Chinese medicine(TCM)in the treatment of functional constipation(FC)in children,so as to provide new ideas for the TCM therapy of FC in children.Methods Oral prescriptions for the treatment of FC in children were searched in the Canon of Traditional Chinese Medicine and CNKI,WanFang,VIP,Chinese Biomedical Literature Database.The compositions of ancient prescriptions and modern prescriptions were collected,and the ancient and modern prescription databases were established respectively.The databases were imported into the Traditional Chinese Medicine Inheritance Computing Platform.The frequency statistics,association rule analysis and cluster analysis of the drugs in the prescription were performed on the platform.Results A total of 206 ancient prescriptions were included,involving 149 kinds of traditional Chinese medicines.The medicinal properties are mainly cold.The main flavor is bitter.Purgative herbs and Qi-regulating medicines are used most frequently.The commonly used medicine pairs are Yuliren(Pruni Semen)-Dahuang(Rhei Radix Et Rhizoma)and Mangxiao(Natrii Sulfas)-Dahuang(Rhei Radix Et Rhizoma).A total of 89 modern prescriptions were included,involving 107 kinds of traditional Chinese medicines.The medicinal properties are mainly warm.The main flavor is sweet.Tonifying deficiency medicines and Qi-regulating medicines are used most frequently.Commonly used medicine pair is Gancao(Glycyrrhizae Radix Et Rhizoma),Zhishi(Aurantii Fructus Immaturus),Huomaren(Cannabis Fructus).Ancient and modern medicine meridians are mainly spleen meridian,stomach meridian,lung meridian and large intestine meridian,involving heart meridian,liver meridian and kidney meridian.Both ancient and modern prescriptions are divided into three types of medicine combinations.Conclusion Both ancient and modern doctors pay attention to regulating Qi in order to restore the conduction function of large intestine.The ancient doctors emphasize the use of purging excess,but the m

关 键 词：便秘 数据挖掘 中医药疗法 未成年人 

分 类 号：R256.35[医药卫生—中医内科学]