基于“阴阳交感”及临床药理探讨“黄连-肉桂”对失眠的治疗  

Discussion on the Treatment of Insomnia by“Huanglian(Coptidis Rhizoma)-Rougui(Cinnamomi Cortex)”Based on“Interaction of Yin and Yang”and Clinical Pharmacology

作　　者：姜雷 朱翠玲[1] 吕贵英 岳朝冲 宋淼豫 JIANG Lei;ZHU Cuiling;LYU Guiying;YUE Chaochong;SONG Miaoyu(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450014,Henan,China;The Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450002,Henan,China)

机构地区：[1]河南中医药大学第一附属医院,河南郑州450014 [2]河南中医药大学第二附属医院,河南郑州450002

出　　处：《辽宁中医药大学学报》2024年第6期116-119,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家中医药管理局科技项目(GZY-KJS-2022-044-2);河南省中医药科学研究专项课题(2023ZY2027);郑州市科技惠民计划项目(2020KJHM0017)。

摘　　要：药物配伍是中医的魂之所在,用药如用兵,善用方者,必善药之配伍,执简驭繁。失眠皆因阳盛阴衰,阴阳失交所致,而临床上心肾不交型失眠尤为多见。黄连,味苦性寒,有泻火之功,当属阴药;肉桂,味辛甘、性大热,有补火助阳、引火归元之功,当属阳药。“黄连-肉桂”配伍,交通心肾阴阳二气,可治阴阳失调、心肾不交所致失眠之症。“黄连-肉桂”联用效果更显著,一种可能是由于两药联用后会使有效成分的溶出率更高,还有一种可能是会增多或抑制相关蛋白的表达。通过探讨“黄连-肉桂”所体现的阴阳交感的中医思想,不仅可以为治疗阴阳失调提供新的思路,也可以通过现代药理研究预测出治疗失眠的新机制,并通过实验进行药效验证,为中西医结合治疗失眠打开新思路。Drug pairing is the soul of traditional Chinese medicine,medicine such as military,good use of the formula,must be good drug pairing,the execution of simple and complex.Insomnia is caused by the decline of Yang and Yin,Yin and Yang are out of sync,and clinically,the insomnia of the heart and kidney type is particularly significant.Huanglian(Coptidis Rhizoma),has bitter taste and cold nature,with the function of purging fire,it should be considered Yin medicine;Rougui(Cinnamomi Cortex),has pungent and sweet taste and strong heat nature,with the function of tonifying fire and aiding Yang,returning fire to the origin,it should be considered Yang medicine.The combination of Huanglian(Coptidis Rhizoma)-Rougui(Cinnamomi Cortex)can communicate Yin and Yang of the heart and kidney,and treat the imbalance of Yin and Yang,as well as insomnia caused by heart kidney disharmony.The combination of Huanglian(Coptidis Rhizoma)-Rougui(Cinnamomi Cortex)is more effective,one possibility is that the combination of the two drugs will lead to a higher dissolution rate of the active ingredient,and another possibility is that it will increase or inhibit the expression of the relevant proteins.By exploring the traditional Chinese medicine idea of interaction of Yin and Yang embodied in Huanglian(Coptidis Rhizoma)-Rougui(Cinnamomi Cortex),we can provide new ideas for the treatment of Yin and Yang disorders,and we can also predict a new mechanism for the treatment of insomnia through modern pharmacological research,and verify the efficacy of the drug through experiments,so as to open up a new way of combining traditional Chinese and Western medicine in the treatment of insomnia.

关 键 词：药对 黄连-肉桂 阴阳交感 失眠 

分 类 号：R256.23[医药卫生—中医内科学]