When does the Human Heart Transition from Hyperplastic Myocyte Growth to Myocyte Hypertrophy?  

作　　者：A Martin Gerdes 

机构地区：[1]New York Institute of Technology,College of Osteopathic Medicine,Old Westbury,New York 11568,USA.

出　　处：《Cardiology Discovery》2021年第3期202-203,共2页心血管病探索（英文）

摘　　要：At some point after birth,myocyte hyperplasia ceases,and myocyte hypertrophy accounts for the remaining growth of myocytes composing the heart from that point forward.Heart weight increases in proportion to myocyte volume after this transition.In rat heart,this transition occurs abruptly at postnatal day 4.[1]The transition point in humans is unknown and has proven very difficult to identify from a technical standpoint.For instance,even if autopsied hearts were optimally preserved,which is unlikely,it is difficult to definitively distinguish between mitosis in myocytes and non-myocytes in many cases.Additionally,karyokinesis(binucleation/multinucleation)continues as myocytes hypertrophy after cessation of cytokinesis.So,mitosis is not a definitive marker of myocyte proliferation.Identifying the transition point in humans is of scientific interest and potentially helpful in timing surgical procedures necessary to correct congenital heart defects.For instance,timing surgery before the transition may beneficially affect cardiac myocytes in adulthood.With conditions such as hypoplastic left heart syndrome,optimal surgical timing could make a difference in outcomes if surgery could be completed during the myocyte hyperplastic period before the heart has lost the ability to make new myocytes.Theoretically,these hearts may then have a normal complement of left ventricular myocytes upon reaching adulthood.

关 键 词：instance optimal TRANSITION 

分 类 号：X70[环境科学与工程—环境工程]